Structure of a split yeast gene: complete nucleotide sequence of the actin gene in Saccharomyces cerevisiae.
Structure of a split yeast gene: complete nucleotide sequence of the actin gene in Saccharomyces cerevisiae.
复制标题
分裂酵母基因的结构：酿酒酵母中肌动蛋白基因的完整核苷酸序列。
DOI：
10.1073/pnas.77.5.2546
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发表时间：
1980
影响因子：
11.1
通讯作者：
I. Sures
中科院分区：
文献类型：
--
作者：
D. Gallwitz;I. Sures
The complete nucleotide sequence of the actin gene from Saccharomyces cerevisiae has been determined. The coding region is interrupted by a 304-base-pair intervening sequence that is located within the triplet coding for amino acid 4. DNA sequences of the intron-exon junctions are similar to those found in higher eukaryotes and can be aligned such that the intron starts with the dinucleotide 5'-G-T-3' and ends with 5'-A-G-3'. Regions fo homology within the sequences upstream from the initiation codon and those following the termination codon have been detected between the yeast iso-1-cytochrome c gene and the actin gene. As deduced from the nucleotide sequence, yeast actin has 374 amino acid residues. Its primary structure, especially the NH2-terminal third of the protein, is highly conserved during evolution.
