Intergenerational adaptations to stress are evolutionarily conserved, stress-specific, and have deleterious trade-offs.
Intergenerational adaptations to stress are evolutionarily conserved, stress-specific, and have deleterious trade-offs.
复制标题
对压力的代际适应在进化上是保守的，压力特异性的，并且具有有害的权衡。
DOI：
10.7554/elife.73425
复制
发表时间：
2021-10-08
期刊：
影响因子：
7.7
通讯作者：
Miska EA
中科院分区：
文献类型：
--
作者：
Burton NO;Willis A;Fisher K;Braukmann F;Price J;Stevens L;Baugh LR;Reinke A;Miska EA
Despite reports of parental exposure to stress promoting physiological adaptations in progeny in diverse organisms, there remains considerable debate over the significance and evolutionary conservation of such multigenerational effects. Here, we investigate four independent models of intergenerational adaptations to stress in Caenorhabditis elegans – bacterial infection, eukaryotic infection, osmotic stress, and nutrient stress – across multiple species. We found that all four intergenerational physiological adaptations are conserved in at least one other species, that they are stress -specific, and that they have deleterious tradeoffs in mismatched environments. By profiling the effects of parental bacterial infection and osmotic stress exposure on progeny gene expression across species, we established a core set of 587 genes that exhibited a greater than twofold intergenerational change in expression in response to stress in C. elegans and at least one other species, as well as a set of 37 highly conserved genes that exhibited a greater than twofold intergenerational change in expression in all four species tested. Furthermore, we provide evidence suggesting that presumed adaptive and deleterious intergenerational effects are molecularly related at the gene expression level. Lastly, we found that none of the effects we detected of these stresses on C. elegans F1 progeny gene expression persisted transgenerationally three generations after stress exposure. We conclude that intergenerational responses to stress play a substantial and evolutionarily conserved role in regulating animal physiology and that the vast majority of the effects of parental stress on progeny gene expression are reversible and not maintained transgenerationally.
