White matter lesions and season of birth of patients with bipolar affective disorder
White matter lesions and season of birth of patients with bipolar affective disorder
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DOI：
10.1176/appi.ajp.158.9.1521
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发表时间：
2001-09-01
影响因子：
17.7
通讯作者：
Ferrier, IN
中科院分区：
文献类型：
--
作者：
Moore, PB;El-Badri, SM;Ferrier, IN
目的：通过对79例双相情感障碍(DSM-IV)患者进行磁共振成像(MRI)检查，探讨出生季节与脑白质病变的关系。方法：对79例双相情感障碍(DSM-IV)患者行MRI检查，检查皮质下深层及脑室周围白质病变。结果：13例患者表现为皮质下深层白质病变，其中9例(69.2%)出生在冬季(1~3月)。这些患者中有7人虽然接受了超过两年的适当治疗，但仍有症状。结论：出生季节、疾病转归和皮质下深层白质病变似乎密切相关。深皮质下白质损害可能是宫内中毒性或感染性侮辱的标志。
Objective: it is established that patients with bipolar disorder have an excess of births in winter or early spring, The authors investigated a link between season of birth and white matter lesions with magnetic resonance imaging (MRI).Method: T-2-weighted and proton density MRI scans were examined for 79 patients with bipolar disorder (DSM-IV) for the presence of deep subcortical and periventricular white matter lesions. The birth seasons of patients with white matter lesions were compared with those of the general population.Results: Thirteen subjects exhibited deep subcortical white matter lesions, of whom nine (69.2%) were born in the winter months (January to March). Seven of these patients remained symptomatic, despite adequate treatment for more than 2 yea rs.Conclusions: Birth season, illness outcome, and deep subcortical white matter lesions appear to be closely linked. Deep subcortical white matter lesions may be a marker of a toxic or infective insult in utero.