Tissue engineering and the intervertebral disc: the challenges
Tissue engineering and the intervertebral disc: the challenges
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DOI：
10.1007/s00586-008-0746-2
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发表时间：
2008-12-01
影响因子：
2.8
通讯作者：
Urban, Jill P. G.
中科院分区：
文献类型：
--
作者：
Kandel, Rita;Roberts, Sally;Urban, Jill P. G.
椎间盘退变是一种常见的疾病。虽然与此相关的背痛很少危及生命，但每年在发病率、生产力损失、医疗费用和工人赔偿福利方面的成本是巨大的。目前实践的外科手术干预是针对移除受损或改变的组织。开发新的治疗方式是至关重要的，因为越来越多的人认为目前用于症状性退行性椎间盘疾病的策略可能无效。因此，需要开发一种全新的方法来治疗这种疾病;再生医学和组织工程方法在这方面显得特别有前途。本文综述了目前限制这种方法治疗椎间盘退变的临床应用的一些挑战。
Disc degeneration is a common disorder. Although the back pain that can develop in association with this is rarely life-threatening, the annual cost in terms of morbidity, lost productivity, medical expenses and workers' compensation benefits is significant. Surgical intervention as practised currently is directed towards removing the damaged or altered tissue. Development of new treatment modalities is critical as there is a growing consensus that the strategies used currently for symptomatic degenerative disc disease may not be effective. Accordingly, there is a need to develop an entirely new way to treat this disorder; regenerative medicine and tissue engineering approaches appear particularly promising in this regard. This paper reviews some of the challenges that currently are limiting the clinical application of this approach to the treatment of disc degeneration.