Atypical metaplasia and incidence of bronchogenic carcinoma.
Atypical metaplasia and incidence of bronchogenic carcinoma.
复制标题
不典型化生和支气管癌的发病率。
DOI：
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发表时间：
1990
影响因子：
5
通讯作者：
G. Samsa
中科院分区：
文献类型：
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作者：
M. Vine;V. Schoenbach;B. Hulka;G. Koch;G. Samsa
呼吸道不典型鳞状上皮化生的预后意义尚不确定，特别是对于轻度的呼吸道疾病。在14，414名45岁或以上每天吸烟一包或多包的男性中，评估了痰细胞学检测的不典型化生严重程度与支气管肺癌发病率之间的关系。作为国家癌症研究所早期肺癌检测合作项目的一部分，试验参与者每4个月接受一次痰细胞学评估，平均持续7.4年，并在1971年至1983年期间在三个机构进行肺癌发展的随访：约翰霍普金斯大学，纪念斯隆-凯特琳癌症中心和马约诊所。Logistic回归分析控制了年龄、种族、职业性肺癌暴露、每年平均细胞学检查记录数和吸烟习惯，结果显示，与细胞学检查阴性的男性相比，轻度支气管炎男性发生支气管肺癌的相对发生率（RR）估计值更高，但不同机构之间存在显著差异（约翰霍普金斯大学RR = 1.1，95%置信区间（CI）0.8-1.5;纪念斯隆-凯特琳癌症中心RR = 1.6，95% CI 1.1-2.5;马约诊所RR = 2.5，95% CI 1.6-4.0）。结果提示，痰细胞学检查发现的轻度痰液增多是支气管肺癌风险适度升高的指标。
The prognostic implication of atypical squamous metaplasia of the respiratory tract has been uncertain, especially for mild atypia. The relation between degree of severity of atypical metaplasia as detected by sputum cytology and incidence of bronchogenic carcinoma was assessed among 14,414 men aged 45 years or older who smoked one or more packs of cigarettes per day. Trial participants underwent sputum cytologic evaluations every 4 months for an average of 7.4 years as part of the Cooperative Early Lung Cancer Detection Program of the National Cancer Institute and were followed for the development of lung cancer between 1971 and 1983 at three institutions: The Johns Hopkins University, the Memorial Sloan-Kettering Cancer Center, and the Mayo Clinic. Analysis with logistic regression controlling for age, race, occupational exposures to lung carcinogens, average number of cytology records per year, and smoking habits revealed that the estimate of the relative rate (RR) of developing bronchogenic carcinoma was greater among men who had mild atypia as compared with men who had negative cytology readings, but there were marked differences among institutions (RR = 1.1, 95% confidence interval (Cl) 0.8-1.5 at The Johns Hopkins University; RR = 1.6, 95% Cl 1.1-2.5 at the Memorial Sloan-Kettering Cancer Center; and RR = 2.5, 95% Cl 1.6-4.0 at the Mayo Clinic). Results suggest that mild atypia as detected by cytologic evaluation of sputum is an indicator of a modest elevation in risk of bronchogenic carcinoma.