Functional classification analysis of somatically mutated genes in human breast and colorectal cancers
Functional classification analysis of somatically mutated genes in human breast and colorectal cancers
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DOI：
10.1016/j.ygeno.2008.03.002
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发表时间：
2008-06-01
期刊：
影响因子：
4.4
通讯作者：
Quackenbush, John
中科院分区：
文献类型：
--
作者：
Chittenden, Thomas W.;Howe, Eleanor A.;Quackenbush, John
Sjoblom 及其同事最近发表的一项研究 [T.索布洛姆，S.琼斯，L.D.伍德，D.W.帕森斯，J.林，T.D.巴伯，D.曼德尔克，RJ。利里，J. Ptak、N. Silliman、S. Szabo、P. Buckhaults、C. Farrell、P. Meeh、S.D.马科维茨，J.威利斯，D.道森，J.K.威尔森、A.F. Gazdar、J. Hartigan、L. Wu、C. Liu、G. Parmigiani、B.H.帕克，K.E.巴赫曼 (Bachman)，N. 帕帕佐普洛斯 (Papadopoulos)，B. 沃格尔斯坦 (Vogelstein)，K.W.金兹勒，V.E. Velculescu，人类乳腺癌和结直肠癌的共有编码序列。 Science 314 (2006) 268-274.] 对 13,023 个人类基因进行了全面测序，并鉴定了乳腺癌和结直肠肿瘤特异性基因的突变，从而深入了解器官特异性肿瘤生物学。在这里，我们对 Sjoblom 的“CAN”基因（这些经过验证的突变基因的一个子集）的功能分类进行了系统分析，确定了与疾病特异性病因相关的新的器官特异性生物学主题和分子途径。该分析通过已建立的 TGF-β1 调节的相互作用，将与不同肿瘤类型相关的四个体细胞突变基因与结直肠癌和乳腺癌联系起来，揭示了这些癌症的机制差异，并提供了潜在的诊断和治疗靶点。 (C) 2008 Elsevier Inc. 保留所有权利。
A recent study published by Sjoblom and colleagues [T. Sjoblom, S. Jones, L.D. Wood, D.W. Parsons, J. Lin, T.D. Barber, D. Mandelker, RJ. Leary,J. Ptak, N. Silliman, S. Szabo, P. Buckhaults, C. Farrell, P. Meeh, S.D. Markowitz,J. Willis, D. Dawson,J.K. Willson, A.F. Gazdar, J. Hartigan, L. Wu, C. Liu, G. Parmigiani, B.H. Park, K.E. Bachman, N. Papadopoulos, B. Vogelstein, K.W. Kinzler, V.E. Velculescu, The consensus coding sequences of human breast and colorectal cancers. Science 314 (2006) 268-274.] performed comprehensive sequencing of 13,023 human genes and identified mutations in genes specific to breast and colorectal tumors, providing insight into organ-specific tumor biology. Here we present a systematic analysis of the functional classifications of Sjoblom's "CAN" genes, a subset of these validated mutant genes, that identifies novel organ-specific biological themes and molecular pathways associated with disease-specific etiology. This analysis links four somatically mutated genes associated with diverse oncological types to colorectal and breast cancers through established TGF-beta 1-regulated interactions, revealing mechanistic differences in these cancers and providing potential diagnostic and therapeutic targets. (C) 2008 Elsevier Inc. All rights reserved.