GLUT-1 expression in pancreatic neoplasia: implications in pathogenesis, diagnosis, and prognosis.
GLUT-1 expression in pancreatic neoplasia: implications in pathogenesis, diagnosis, and prognosis.
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DOI：
10.1097/mpa.0b013e318201c935
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发表时间：
2011-03
期刊：
影响因子：
2.9
通讯作者：
Adsay NV
中科院分区：
文献类型：
--
作者：
Basturk O;Singh R;Kaygusuz E;Balci S;Dursun N;Culhaci N;Adsay NV
已经发现GLUT-1在多种细胞途径的上调中具有重要作用，并且涉及与恶性肿瘤的生物学行为相关的肿瘤转化。然而，关于GLUT-1表达在胰腺肿瘤中的意义的文献有限且存在争议。GLUT-1的免疫组织化学表达在各种胰腺肿瘤中进行了检测，包括导管腺癌（DA）、胰腺上皮内肿瘤（PanIN）、导管内乳头状粘液性肿瘤（IPMN）和浆液性囊腺瘤。从低级别到高级别异型增生病变，GLUT-1的表达逐渐增加：所有高级别PanIN/IPMNs（中度/高度异型增生）均显示出明显的GLUT-1表达。在分析的94个DA中，46个DA中有极轻微/中度表达，24个DA中有显著表达。然而，所有4种DA透明细胞变体均显示出显著的GLUT-1免疫标记，其他DA中观察到的透明细胞变化区域也是如此。此外，所有12例浆液性囊腺瘤均表达显著的GLUT-1。GLUT-1表达与DA组织学分级（P = 0.016）和肿瘤大小（P = 0.03）直接相关。GLUT-1可能通过诱导糖原在细胞质中的积累而引起这些肿瘤的独特的透明细胞外观。此外，由于GLUT-1表达与DA的组织学分级和肿瘤大小有关，因此需要进一步研究GLUT-1与预后和肿瘤进展的关系。
GLUT-1 has been found to have an important role in the upregulation of various cellular pathways and implicated in neoplastic transformation correlating with biological behavior in malignancies. However, literature regarding the significance of GLUT-1 expression in pancreatic neoplasia has been limited and controversial. Immunohistochemical expression of GLUT-1 was tested in a variety of pancreatic neoplasia including ductal adenocarcinomas (DAs), pancreatic intraepithelial neoplasms (PanINs), intraductal papillary mucinous neoplasms (IPMNs), and serous cystadenomas. There was a progressive increase in the expression of GLUT-1 from low- to higher-grade dysplastic lesions: All higher-grade PanINs/IPMNs (the ones with moderate/high-grade dysplasia) revealed noticeable GLUT-1 expression. Among the 94 DAs analyzed, there were minimal/moderate expression in 46 and significant expression in 24 DAs. However, all 4 clear-cell variants of DAs revealed significant GLUT-1 immunolabeling, as did areas of clear-cell change seen in other DAs. Moreover, all 12 serous cystadenomas expressed significant GLUT-1. GLUT-1 expression was also directly correlated with DA histological grade (P = 0.016) and tumor size (P = 0.03). GLUT-1 may give rise to the distinctive clear-cell appearance of these tumors by inducing the accumulation of glycogen in the cytoplasm. Additionally, because GLUT-1 expression was related to histological grade and tumor size of DA, further studies are warranted to investigate the association of GLUT-1 with prognosis and tumor progression.