Pyruvate dehydrogenase activation in adipocyte mitochondria by an insulin-generated mediator from muscle.
Pyruvate dehydrogenase activation in adipocyte mitochondria by an insulin-generated mediator from muscle.
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肌肉产生的胰岛素介质激活脂肪细胞线粒体中的丙酮酸脱氢酶。
DOI：
10.1126/science.505013
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发表时间：
1979
期刊：
影响因子：
56.9
通讯作者：
J. Seals
中科院分区：
文献类型：
--
作者：
L. Jarett;J. Seals
胰岛素处理的肌肉提取物的色谱组分中的物质刺激了脂肪细胞线粒体中丙酮酸脱氢酶的活性。这种作用类似于胰岛素对质膜-线粒体混合物中酶的激活。无论是色谱馏分，也不胰岛素需要腺苷三磷酸或镁离子（Mg 2+），这表明这两种药物通过钙敏感的磷酸酶。该部分可能含有胰岛素作用的化学介质。
Material in a chromatographic fraction from an extract of insulin-treated muscle stimulated pyruvate dehydrogenase activity in addipocyte mitochondria. This action was similar to insulin's activation of the enzyme in a plasma membrane-mitochondria mixture. Neither the chromatographic fraction nor insulin required adenosine triphosphate or magnesium ion (Mg2+), suggesting that both agents acted through a calcium-sensitive phosphatase. This fraction may contain a chemical mediator of insulin action.