The Gracefully Aging Immune System
The Gracefully Aging Immune System
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DOI：
10.1126/scitranslmed.3005624
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发表时间：
2013-05-15
影响因子：
17.1
通讯作者：
Del Giudice, Giuseppe
中科院分区：
文献类型：
--
作者：
Boraschi, Diana;Aguado, M. Teresa;Del Giudice, Giuseppe
人类在世纪取得的最大成就之一就是延长了预期寿命。然而，人类寿命的大幅增长又迎来了一个新的关注点：健康老龄化。由于传染病是特别脆弱的老年人口发病的主要原因，预防这些疾病的战略将对改善健康老龄化产生明显影响。因此，需要为老年人量身定制的疫苗和免疫策略，并且疫苗的开发应考虑到年龄引起的免疫应答的特殊变化。最近在意大利锡耶纳举行的“衰老与免疫”会议回顾并讨论了免疫衰老的几种可能原因，以及对抗免疫应答减弱和恢复免疫能力的策略。此外，还考虑了老年人应接种疫苗的疾病的例子。
Prolonged life expectancy in the 20th century has been one of humankind's greatest triumphs. However, the substantial increase in the human life span has ushered in a new concern: healthy aging. Because infectious diseases prominently contribute to morbidity in the particularly vulnerable elderly population, strategies for preventing these diseases would have a clear impact on improving healthy aging. Thus, vaccines and immunization strategies tailored for the elderly population are needed, and vaccines should be developed to take into consideration the peculiar age-induced variations of immune responsiveness. The conference "Ageing and Immunity" recently held in Siena, Italy, has reviewed and discussed several possible causes of immune senescence, as well as strategies for counteracting this waning of immune responsiveness and for restoring immunocompetence. In addition, examples of diseases that should be targeted by vaccination in the senior population were considered.