Interval time coding by neurons in the presupplementary and supplementary motor areas
Interval time coding by neurons in the presupplementary and supplementary motor areas
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DOI：
10.1038/nn.2272
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发表时间：
2009-04-01
影响因子：
25
通讯作者：
Tanji, Jun
中科院分区：
文献类型：
--
作者：
Mita, Akihisa;Mushiake, Hajime;Tanji, Jun
间隔时间是行为的一种重要的指导力量。先前的研究表明，前额叶和顶叶皮层参与了时间知觉和时间决策。我们发现，在内侧运动区，特别是前补充运动区的神经元，参与间隔计时秒的范围内。猴子被训练来执行一项间隔生成任务，该任务要求它们确定三种不同持续时间的等待时间。神经元活动有助于从视觉线索中检索时间指令的过程，以时间选择性的方式发出行动开始的信号，并开发活动来代表时间的流逝。这些结果说明内侧运动区如何参与发起行动的基础上自我产生的时间估计。
Interval timing is an essential guiding force of behavior. Previous reports have implicated the prefrontal and parietal cortex as being involved in time perception and in temporal decision making. We found that neurons in the medial motor areas, in particular the presupplementary motor area, participate in interval timing in the range of seconds. Monkeys were trained to perform an interval-generation task that required them to determine waiting periods of three different durations. Neuronal activity contributed to the process of retrieving time instructions from visual cues, signaled the initiation of action in a time-selective manner, and developed activity to represent the passage of time. These results specify how medial motor areas take part in initiating actions on the basis of self-generated time estimates.