Fast lesion mapping during HIFU treatment using harmonic motion imaging guided focused ultrasound (HMIgFUS) in vitro and in vivo.
Fast lesion mapping during HIFU treatment using harmonic motion imaging guided focused ultrasound (HMIgFUS) in vitro and in vivo.
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DOI：
10.1088/1361-6560/aa6024
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发表时间：
2017-04-21
影响因子：
3.5
通讯作者：
Konofagou E
中科院分区：
文献类型：
--
作者：
Han Y;Wang S;Payen T;Konofagou E
高强度聚焦超声(HIFU)消融的成功临床应用有赖于对病变形成的可靠监测。谐波运动成像引导聚焦超声(HMIGFUS)是一种基于超声的弹性成像技术，它根据组织的硬度变化来监测HIFU消融，而不是传统的B型超声监测中的回声强度变化，从而使其对病变的发展更敏感。我们的小组已经证明，在HMIGFUS中，基于辐射力激发区域预测病变位置是可行的。在这项研究中，探讨了一种快速的病变标测方法在HIFU中直接监测病变图的可行性。通过从要在计算机显示器上流传输的当前HMI峰间位移图中减去参考HMI图像来生成HMI损伤图。将HMIgFUS病变的大小与大体病理进行比较。病变深度(R2=0.81，斜率=0.90)、宽度(R2=0.85，斜率=1.12)和面积(R2=0.58，斜率=0.75)具有良好的一致性。体内可行性是在一只患有胰腺肿瘤的小鼠身上评估的。这些结果表明，HMIgFUS可以成功地标测热损伤并实时监测体内外病变的发展。因此，HMIgFUS技术可能成为HIFU治疗监测的一种新的临床工具。
The successful clinical application of High Intensity Focused Ultrasound (HIFU) ablation depends on reliable monitoring of the lesion formation. Harmonic Motion Imaging guided Focused Ultrasound (HMIgFUS) is an ultrasound-based elasticity imaging technique, which monitors HIFU ablation based on the stiffness change of the tissue instead of the echo intensity change in conventional B-mode monitoring, rendering it potentially more sensitive to lesion development. Our group has shown that predicting the lesion location based on the radiation force-excited region is feasible during HMIgFUS. In this study, the feasibility of a fast lesion mapping method is explored to directly monitor the lesion map during HIFU. The HMI lesion map was generated by subtracting the reference HMI image from the present HMI peak-to-peak displacement map to be streamed on the computer display. The dimensions of the HMIgFUS lesions were compared against gross pathology. Excellent agreement was found between the lesion depth (r2 = 0.81, slope = 0.90), width (r2 = 0.85, slope = 1.12) and area (r2 = 0.58, slope = 0.75). In vivo feasibility was assessed in a mouse with a pancreatic tumor. These findings demonstrate that HMIgFUS can successfully map thermal lesion and monitor lesion development in real time in vitro and in vivo. The HMIgFUS technique may therefore constitute a novel clinical tool for HIFU treatment monitoring.