Stress Relief Techniques: p38 MAPK Determines the Balance of Cell Cycle and Apoptosis Pathways.
Stress Relief Techniques: p38 MAPK Determines the Balance of Cell Cycle and Apoptosis Pathways.
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DOI：
10.3390/biom11101444
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发表时间：
2021-10-02
期刊：
影响因子：
5.5
通讯作者：
Cook JG
中科院分区：
文献类型：
--
作者：
Whitaker RH;Cook JG
蛋白质信号传导网络是由不同的和相互连接的细胞信号传导途径汇聚成功能和调节网络而形成的。这些信号通路通常通过一系列翻译后修饰（如磷酸化）或通过内在基序的蛋白质-蛋白质相互作用来接收和传导分子信息。丝裂原活化蛋白激酶（MAPK）是通过磷酸化传递信号的激酶级联的组分。有几个MAPK亚家族，其中一个亚家族是应激活化蛋白激酶，在哺乳动物中是p38家族。p38酶介导多种细胞结果，包括DNA修复、细胞存活/细胞命运决定和细胞周期停滞。细胞周期本身是一个信号系统，精确控制DNA复制，染色体分离和细胞分裂。受p38应激反应影响的另一个不可或缺的细胞功能是程序性细胞死亡（凋亡）。作为细胞存活的调节因子，BCL 2蛋白家族及其动力学对细胞应激非常敏感。BCL 2家族形成蛋白质-蛋白质相互作用网络，分为抗凋亡和促凋亡成员，这两个方面之间的结合平衡决定细胞存活。在这里，我们讨论了p38 MAPK，细胞周期和凋亡信号通路之间的交叉点。
Protein signaling networks are formed from diverse and inter-connected cell signaling pathways converging into webs of function and regulation. These signaling pathways both receive and conduct molecular messages, often by a series of post-translation modifications such as phosphorylation or through protein–protein interactions via intrinsic motifs. The mitogen activated protein kinases (MAPKs) are components of kinase cascades that transmit signals through phosphorylation. There are several MAPK subfamilies, and one subfamily is the stress-activated protein kinases, which in mammals is the p38 family. The p38 enzymes mediate a variety of cellular outcomes including DNA repair, cell survival/cell fate decisions, and cell cycle arrest. The cell cycle is itself a signaling system that precisely controls DNA replication, chromosome segregation, and cellular division. Another indispensable cell function influenced by the p38 stress response is programmed cell death (apoptosis). As the regulators of cell survival, the BCL2 family of proteins and their dynamics are exquisitely sensitive to cell stress. The BCL2 family forms a protein–protein interaction network divided into anti-apoptotic and pro-apoptotic members, and the balance of binding between these two sides determines cell survival. Here, we discuss the intersections among the p38 MAPK, cell cycle, and apoptosis signaling pathways.
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