Regulation of multidrug resistance by microRNAs in anti-cancer therapy.
Regulation of multidrug resistance by microRNAs in anti-cancer therapy.
复制标题
抗癌治疗中microRNA对多药耐药性的调节
DOI：
10.1016/j.apsb.2016.09.002
复制
发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Zhu H
中科院分区：
文献类型：
--
作者：
An X;Sarmiento C;Tan T;Zhu H
多药耐药性（MDR）仍然是成功癌症治疗的主要临床障碍。尽管MDR的多种机制已得到很好的阐明，例如药物转运蛋白的失调、细胞凋亡和自噬机制的缺陷、药物代谢和药物靶标的改变、氧化还原稳态的破坏，但对特定癌症患者中MDR的确切机制以及这些不同机制之间的相互影响以及它们如何调节仍知之甚少。 MicroRNA (miRNA) 是一类新型小非编码 RNA，可以通过转录后调节多种靶基因和蛋白质表达来控制细胞的整体活性。越来越多的证据表明，miRNA通过调节上述各种耐药机制在MDR中发挥着关键的调节作用，从而为开发新颖且更有效的个体化癌症治疗方法带来了广阔的前景。这篇综述总结了各种MDR机制，主要关注miRNA在癌症治疗中调节MDR的作用。在这篇综述文章中，我们总结了癌细胞中已知的多药耐药 (MDR) 机制以及 microRNA 在调节这些机制中的作用。我们希望这篇综述能够加深我们对 MDR 的理解，并开发治疗癌症 MDR 的有效方法。
Multidrug resistance (MDR) remains a major clinical obstacle to successful cancer treatment. Although diverse mechanisms of MDR have been well elucidated, such as dysregulation of drugs transporters, defects of apoptosis and autophagy machinery, alterations of drug metabolism and drug targets, disrupti on of redox homeostasis, the exact mechanisms of MDR in a specific cancer patient and the cross-talk among these different mechanisms and how they are regulated are poorly understood. MicroRNAs (miRNAs) are a new class of small noncoding RNAs that could control the global activity of the cell by post-transcriptionally regulating a large variety of target genes and proteins expression. Accumulating evidence shows that miRNAs play a key regulatory role in MDR through modulating various drug resistant mechanisms mentioned above, thereby holding much promise for developing novel and more effective individualized therapies for cancer treatment. This review summarizes the various MDR mechanisms and mainly focuses on the role of miRNAs in regulating MDR in cancer treatment. In this review article, we summarized known mechanisms for multidrug resistance (MDR) in cancer cells and the role of microRNAs in regulating these mechanisms. We hope this review can shed light on our understanding of MDR and developing effective means for treatment of MDR in cancers.