Affective disorder not linked to HLA.
Affective disorder not linked to HLA.
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与 HLA 无关的情感障碍。
DOI：
10.1002/gepi.1370060152
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发表时间：
1989
影响因子：
2.1
通讯作者：
Price,RA
中科院分区：
文献类型：
--
作者：
Price,RA
这些分析集中在情感障碍与HLA的关系。来自安大略的86个先前未发表的家族的样本和来自纽芬兰的10个未发表的谱系，以及原始Weitkamp等人[1981]的20个家族的样本，NIMH [Goldin等人，[1982]（18个家系）和Egeland等[1987]（2个大家系），采用同胞对方法以及全家系的标准连锁分析进行了研究。研究了各种遗传模型。基于分析方法或任何遗传模型，没有证据表明任何样本存在关联。在情感疾病一致、健康一致或情感疾病不一致的兄弟姐妹中，血统相同的基因比例没有差异。没有任何组与50%有显着差异。从全家系的分析中，可以排除与HLA的连锁，距离约为20至25厘摩。没有证据表明存在连锁异质性。这些结果反对情感障碍与HLA的联系。
These analyses focused on the relationship of affective disorders to HLA. The sample of 86 previously unpublished families from Ontario and 10 unpublished pedigrees from Newfoundland, as well as the original Weitkamp et al. [1981] sample of 20 families, the samples provided by NIMH [Goldin et al., 1982] (18 families), and Egeland et al. [1987] (2 large pedigrees), were examined using sib pair methods as well as standard linkage analysis of the full pedigrees. A variety of genetic models were examined. There was no evidence for linkage from any of the samples based on either analytic approach or for any genetic model. Groups of sibling pairs concordant for affective illness, concordant for being well, or discordant for affective illness did not differ in the proportion of genes identical by descent. No group differed significantly from 50%. From the analysis of full pedigrees, linkage to HLA could be excluded to a distance of approximately 20 to 25 centimorgans. There was no evidence for linkage heterogeneity. These results argue against linkage of affective disorder to HLA.