Exploration of Sleep as a Specific Risk Factor for Poor Metabolic and Mental Health: A UK Biobank Study of 84,404 Participants.
Exploration of Sleep as a Specific Risk Factor for Poor Metabolic and Mental Health: A UK Biobank Study of 84,404 Participants.
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DOI：
10.2147/nss.s323160
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发表时间：
2021
影响因子：
3.4
通讯作者：
Anderson KN
中科院分区：
文献类型：
--
作者：
Zhu G;Cassidy S;Hiden H;Woodman S;Trenell M;Gunn DA;Catt M;Birch-Machin M;Anderson KN
睡眠时间长短对身心健康都有不利影响。然而，大多数研究都是基于自我报告的睡眠时间和健康状况。因此，这项纵向研究旨在调查老年人客观测量的睡眠时间和随后的初级卫生保健记录，以调查睡眠时间和碎片对身心健康的影响。使用加速度计测量客观睡眠持续时间的数据。然后从英国生物库（n= 84，404）获得初级保健健康记录。参与者（平均年龄62.4岁）根据从加速度计数据得出的睡眠时间分为五组：<5小时，5-6小时，6-7小时，7-8小时和>8小时。ICD-10编码用于分析初级保健数据。睡眠开始后的觉醒、最不活跃的5小时内的活动水平和睡眠期间的运动发作被分析为睡眠片段化的指示。二元回归模型根据年龄、性别和汤森剥夺评分进行调整。研究发现，睡眠时间与糖尿病、高血压、心脏病和抑郁症等疾病之间呈“U型”关系。短时间和长时间的睡眠以及零碎的睡眠与疾病的几率增加有关。六到八小时的睡眠，以及较少的零碎睡眠，预示着更好的长期代谢和心理健康。
Short and long sleep durations have adverse effects on physical and mental health. However, most studies are based on self-reported sleep duration and health status. Therefore, this longitudinal study aims to investigate objectively measured sleep duration and subsequent primary health care records in older adults to investigate the impact of sleep duration and fragmentation on physical and mental health. Data on objective sleep duration were measured using accelerometry. Primary care health records were then obtained from the UK Biobank (n=84,404). Participants (mean age, 62.4 years) were divided into five groups according to their sleep duration derived from the accelerometry data: <5 hours, 5–6 hours, 6–7 hours, 7–8 hours and >8 hours. ICD-10 codes were used for the analysis of primary care data. Wake after sleep onset, activity level during the least active 5 hours and episodes of movement during sleep were analysed as an indication for sleep fragmentation. Binary regression models were adjusted for age, gender and Townsend deprivation score. A “U-shaped” relationship was found between sleep duration and diseases including diabetes, hypertension and heart disease and depression. Short and long sleep durations and fragmented sleep were associated with increased odds of disease. Six to eight hours of sleep, as well as less fragmented sleep, predicted better long-term metabolic and mental health.