A low interleukin-10 tumor necrosis factor-alpha ratio is associated with malaria anemia in children residing in a holoendemic malaria region in western Kenya.
A low interleukin-10 tumor necrosis factor-alpha ratio is associated with malaria anemia in children residing in a holoendemic malaria region in western Kenya.
复制标题
居住在肯尼亚西部疟疾肆虐地区的儿童中，白细胞介素 10 肿瘤坏死因子-α 比率较低与疟疾贫血有关。
DOI：
--
复制
发表时间：
1999
影响因子：
6.4
通讯作者：
V. Udhayakumar
中科院分区：
文献类型：
--
作者：
C. Othoro;Altaf A. Lal;Bernard L. Nahlen;Davy K. Koech;A. S. Orago;V. Udhayakumar
Th1细胞因子(肿瘤坏死因子-α、干扰素-γ)和Th2细胞因子(白介素10、-4)之间的平衡可能在严重恶性疟疾的发生发展中起关键作用。因此，我们测定了不同疟疾症状的儿童血浆中这些细胞因子的浓度。大多数儿童检测不到血浆中的干扰素-γ和IL-4水平。然而，与对照组相比，高密度寄生虫血症和疟疾贫血组儿童的肿瘤坏死因子-α和IL-10显著升高。在轻度疟疾的儿童中，IL-10显著升高，但不是肿瘤坏死因子-α。在患有疟疾贫血的儿童中，发现肿瘤坏死因子-α的浓度最高，而在高密度、无并发症的疟疾儿童中，IL-10的水平最高。轻度和重度寄生虫血症患儿IL-10/TNF-α平均值(4.64，P<0.005)显著高于疟疾贫血患儿(1.77)。因此，高于肿瘤坏死因子-α的IL-10水平可能通过控制肿瘤坏死因子-α的过度炎症活性来预防疟疾贫血的发生。
The balance between Th1 cytokines (tumor necrosis factor [TNF]-alpha, interferon [IFN]-gamma) and Th2 cytokines (interleukin [IL]-10, -4) may be critical in the development of severe falciparum malaria. Therefore, plasma concentrations of these cytokines were determined in children with various manifestations of malaria. Plasma levels of IFN-gamma and IL-4 were undetectable in most children. However, TNF-alpha and IL-10 were significantly elevated in children with high-density parasitemia and malaria anemia compared with children in control groups. In children with mild malaria, IL-10, but not TNF-alpha, was significantly elevated. While the highest concentrations of TNF-alpha were found in children with malaria anemia, IL-10 levels were highest in children with high-density uncomplicated malaria. The mean ratio of IL-10 to TNF-alpha was significantly higher in children with mild and high-density parasitemia (4.64, P<.005) than in children with malaria anemia (1.77). Thus, higher levels of IL-10 over TNF-alpha may prevent development of malaria anemia by controlling the excessive inflammatory activities of TNF-alpha.
影响因子：
158.5
作者：
GRAU, GE;TAYLOR, TE;LAMBERT, PH
通讯作者：
LAMBERT, PH