Roles of plasma membrane-associated sialidase NEU3 in human cancers
Roles of plasma membrane-associated sialidase NEU3 in human cancers
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DOI：
10.1016/j.bbagen.2007.09.016
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发表时间：
2008-03-01
影响因子：
3
通讯作者：
Yamaguchi, Kazunonri
中科院分区：
文献类型：
--
作者：
Miyagi, Taeko;Wada, Tadashi;Yamaguchi, Kazunonri
在癌症中观察到鞘糖脂的唾液酸化改变作为普遍存在的表型，导致肿瘤相关抗原的出现、异常粘附和跨膜信号传导的干扰。为了了解神经节苷脂异常改变在癌症中的病理意义，我们的研究一直集中在唾液酸酶，这是负责从糖蛋白和糖脂中去除唾液酸。在迄今为止鉴定的人唾液酸酶中，唾液酸酶NEU 3是神经节苷脂降解的关键酶，因为其在质膜中的定位和特异性水解神经节苷脂方面的独特性。NEU3在包括结肠癌和肾癌在内的许多类型的癌症中显著上调，并抑制癌细胞的凋亡。本文就近年来唾液酸酶的变化及其在肿瘤中的意义作一综述。NEU3确实与恶性肿瘤密切相关，因此可能是癌症诊断和治疗的潜在靶点。(c)2007 Elsevier B.V.保留所有权利。
Altered sialylation of glycosphingolipids is observed in cancer as a ubiquitous phenotype, leading to the appearance of tumor-associated antigens, aberrant adhesion and disturbance of transmembrane signaling. To understand the pathological significance of aberrant alterations of gangliosides in cancer, our studies have been focused on sialidase, which is responsible for the removal of sialic acids from glycoproteins and glycolipids. Among human sialidases so far identified, sialidase NEU3 is a key enzyme for ganglioside degradation because of its uniqueness both in its localization in the plasma membrane and in specifically hydrolyzing gangliosides. NEU3 is markedly up-regulated in many types of cancers including colon and renal carcinomas and suppresses apoptosis of cancer cells. The present paper briefly summarizes our recent results on the sialidase alterations and their significance in cancer. NEU3 is indeed closely related to malignancy and thus may be a potential target for cancer diagnosis and therapy. (c) 2007 Elsevier B.V. All rights reserved.