In vitro antifungal drug susceptibilities of Penicillium marneffei from China
In vitro antifungal drug susceptibilities of Penicillium marneffei from China
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我国马尔尼菲青霉菌体外抗真菌药敏试验
DOI：
10.1007/s10156-012-0511-7
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发表时间：
2013-08-01
影响因子：
2.2
通讯作者：
Chen, Jimin
中科院分区：
文献类型：
--
作者：
Liu, Donghua;Liang, Ling;Chen, Jimin
免疫功能低下患者的马尔尼菲青霉感染通常是致命的，但早期使用适当的抗真菌药物治疗可能有良好的预后。为筛选治疗南方地区马尼菲氏单胞菌感染的药物，研究了抗真菌药物对马尼菲氏单胞菌的敏感性。2008 - 2010年，广西从患者身上分离到25株曼尼菲疟原虫，从竹鼠身上分离到14株。采用MIC法测定伏立康唑、氟康唑、伊曲康唑、特比萘芬和两性霉素B对分离菌的活性。伏立康唑对马氏单胞菌的MIC值为0.004 ~ 0.25 mg/l，几何平均值为0.04 mg/l，是其他抗真菌药物中最低的。其他抗真菌药物mic由低到高依次为：伊曲康唑、特比萘芬、两性霉素B、氟康唑。结果表明伏立康唑和伊曲康唑在体外对马尼菲假单胞菌有活性，而特比萘芬在治疗这种酵母菌引起的感染方面可能具有未被认识到的有用性。
Penicillium marneffei infections in immunocompromised patients are often fatal, but early treatment with appropriate antifungal agents may have a good prognosis. To select drugs for treating P. marneffei infection in Southern China, the susceptibilities of antifungal agents against P. marneffei isolates were evaluated. Twenty-five strains of P. marneffei were isolated from patients from 2008 to 2010 in Guangxi Province of China, and 14 strains were isolated from bamboo rats. The activity of voriconazole, fluconazole, itraconazole, terbinafine, and amphotericin B on the isolates was assessed by MIC analysis. Voriconazole MIC against strains of P. marneffei ranged from 0.004 to 0.25 mg/l, and it had the lowest MIC (geometric mean values, 0.04 mg/l) in comparison to the other antifungal agents. The MICs of other antifungal agents, in order of lowest to highest, were as follows: itraconazole, terbinafine, amphotericin B, and fluconazole. The results show voriconazole and itraconazole are active against P. marneffei isolates in vitro, and terbinafine may have unrealized usefulness in the treatment of infections caused by this yeast form.