MORF4L1 suppresses cell proliferation, migration and invasion by increasing p21 and E-cadherin expression in nasopharyngeal carcinoma
MORF4L1 suppresses cell proliferation, migration and invasion by increasing p21 and E-cadherin expression in nasopharyngeal carcinoma
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MORF4L1通过增加鼻咽癌中p21和E-cadherin的表达来抑制细胞增殖、迁移和侵袭
DOI：
10.3892/ol.2018.9588
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发表时间：
2019
期刊：
影响因子：
2.9
通讯作者：
Huang Guofu
中科院分区：
文献类型：
--
作者：
Sang Yi;Zhang Ruhua;Sun Longhua;Chen Kaddie Kwok;Li Si-Wei;Xiong Longxin;Peng Yongjian;Zeng Lei;Huang Guofu
死亡因子4样1（Mortality factor 4-like 1，MORF 4L 1）是组蛋白乙酰转移酶亚组的成员，属于4号染色体死亡因子（Mortality factor on chromosome 4，MORF 4）蛋白类。然而，MORF 4L 1在癌症中的作用在很大程度上是未知的。使用逆转录-定量聚合酶链反应和已发表的数据集，本研究表明，MORF 4L 1的表达在几种癌症，包括鼻咽癌（NPC）的减少。此外，MORF 4L 1启动子的甲基化率在肿瘤细胞中比在正常细胞中显著更高。MORF 4L 1的异位表达可抑制鼻咽癌细胞的增殖、集落形成、迁移和侵袭，而敲低MORF 4L 1可促进鼻咽癌细胞的增殖、集落形成、迁移和侵袭。从机制上讲，本研究表明，MORF 4L 1的功能作为一个肿瘤抑制剂，通过增加p21和E-钙粘蛋白水平。这些发现可能是治疗NPC患者的有用的新靶点。
Mortality factor 4-like 1 (MORF4L1) is a member of a subgroup of histone acetyltransferases and belongs to the mortality factor on chromosome 4 (MORF4) class of proteins. However, the role of MORF4L1 in cancers is largely unknown. Using reverse transcription-quantitative polymerase chain reaction and published datasets, the present study demonstrated that the expression of MORF4L1 is decreased in several cancers, including nasopharyngeal carcinoma (NPC). Additionally, the methylation rate of the promoter of MORF4L1 was identified to be significantly higher in tumour cells than in normal cells. The ectopic expression of MORF4L1 was also revealed to inhibit cell proliferation, colony formation, migration and invasion in NPC, whereas the knockdown of MORF4L1 promoted cell proliferation, colony formation, migration and invasion. Mechanistically, the present study demonstrated that MORF4L1 functions as a tumour suppressor by increasing p21 and E-cadherin levels. These findings may be useful novel targets for treating patients with NPC.