C-reactive protein and myocardial infarction
C-reactive protein and myocardial infarction
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DOI：
10.1016/s0895-4356(01)00502-9
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发表时间：
2002-05-01
影响因子：
7.2
通讯作者：
Tracy, RP
中科院分区：
文献类型：
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作者：
Sakkinen, P;Abbott, RD;Tracy, RP
C-反应蛋白（CRP）已被证明可以预测心血管疾病。预测是否在不同的风险因素分层和短期和长期随访中存在差异尚未明确研究。本报告的目的是评估CRP和心肌梗死（MI）的发展之间的关系超过20年的时间在男性檀香山心脏计划。受试者年龄为48至70岁，在测量CRP水平和随访时无流行病。一个.采用病例对照设计，将369例MI病例与1，348例对照受试者进行比较。校正危险因素后，MI的几率随着CRP水平的升高而升高，最早在5年随访时（P = 0.009）。相关性似乎持续超过这一时间，但15年后，影响变得温和。CRP水平升高的不良反应见于中年男性（≤ 55岁）、无高血压或糖尿病的男性以及不吸烟者（P < 0.05）。虽然在CRP测量时高血压和吸烟的人中也观察到了积极的影响，但研究结果表明，在临床健康男性中，动脉粥样硬化的起源可能与炎症比其他过程更密切相关。(C)2002年爱思唯尔科学公司All rights reserved.
C-reactive protein (CRP) has been shown to predict cardiovascular disease. Whether predictions differ across risk factor strata and for short and long-term follow-up has not been clearly examined. The purpose of this report is to assess the relation between CRP and the development of myocardial infarction (MI) over a 20-year period in men in the Honolulu Heart Program. Subjects were aged 48 to 70 years and free of prevalent disease at the time when CRP levels were measured and follow-up be.-an. Using a case-control design, 369 cases of MI were compared with 1,348 control subjects. After risk factor adjustment, the odds of an MI rose with increasing levels of CRP as early as 5 years into follow-up (P = 0.009). Associations appeared to persist beyond this time, but after 15 years, effects became modest. Adverse effects of an elevated CRP level were observed in middle-aged men (less than or equal to55 years), in men without hypertension or diabetes, and in those who were nonsmokers (P < 0.05). Although positive effects were also observed in those who were hypertensive and smoking at the time of CRP measurement, findings suggest that in clinically healthy men, atherosclerosis could have origins more closely linked with inflammation than with other processes. (C) 2002 Elsevier Science Inc. All rights reserved.