The Trichoplax genome and the nature of placozoans
The Trichoplax genome and the nature of placozoans
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DOI：
10.1038/nature07191
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发表时间：
2008-08-21
期刊：
影响因子：
64.8
通讯作者：
Rokhsar, Daniel S.
中科院分区：
文献类型：
--
作者：
Srivastava, Mansi;Begovic, Emina;Rokhsar, Daniel S.
可以说，作为最简单的自由生活的动物，盾形动物可能代表了一种原始的后生动物形式，但他们的生物学知之甚少。在这里，我们报告的序列和分析的类似98万碱基对的盘形动物粘毛板的核基因组。全基因组系统发育分析表明，扁形动物属于一个“真后生动物”分支，包括刺胞动物和两侧动物，海绵是最早分化的动物。紧凑的基因组显示保守的基因内容，基因结构和同线性关系的人类和其他复杂的真后生动物基因组。尽管Trichoplax的细胞和生物体简单，但其基因组编码丰富的转录因子和信号传导途径基因，这些基因通常与真后生动物的不同细胞类型和发育过程相关，从而激发了对神秘细胞复杂性和/或尚未观察到的生活史阶段的进一步研究。
As arguably the simplest free- living animals, placozoans may represent a primitive metazoan form, yet their biology is poorly understood. Here we report the sequencing and analysis of the similar to 98 million base pair nuclear genome of the placozoan Trichoplax adhaerens. Whole- genome phylogenetic analysis suggests that placozoans belong to a 'eumetazoan' clade that includes cnidarians and bilaterians, with sponges as the earliest diverging animals. The compact genome shows conserved gene content, gene structure and synteny in relation to the human and other complex eumetazoan genomes. Despite the apparent cellular and organismal simplicity of Trichoplax, its genome encodes a rich array of transcription factor and signalling pathway genes that are typically associated with diverse cell types and developmental processes in eumetazoans, motivating further searches for cryptic cellular complexity and/ or as yet unobserved life history stages.