Dietary flavonoid intake and incident coronary heart disease: the REasons for Geographic and Racial Differences in Stroke (REGARDS) study
Dietary flavonoid intake and incident coronary heart disease: the REasons for Geographic and Racial Differences in Stroke (REGARDS) study
复制标题
DOI：
10.3945/ajcn.115.129452
复制
发表时间：
2016-11-01
影响因子：
7.1
通讯作者：
Vaccarino, Viola
中科院分区：
文献类型：
--
作者：
Goetz, Margarethe E.;Judd, Suzanne E.;Vaccarino, Viola
背景资料：黄酮类化合物是一种膳食多酚化合物，具有多种有益的心血管作用，但在地理和种族多样的美国样本中，对黄酮类化合物摄入量与冠心病（CHD）发病率之间关系的前瞻性研究有限。目的：随着新的，扩大的美国农业部类黄酮数据库的使用，我们评估了总类黄酮和类黄酮亚类摄入量与出生年龄和地理位置不同的队列中冠心病事件之间的关系，以及年龄、性别、种族和居住地区的影响。设计：参与者是16,678名黑人和白色男性和女性，他们参加了REGARDS（中风的地理和种族差异的原因）研究，这是一项全国前瞻性队列研究。所有参与者在基线时都没有CHD，并且都完成了Block 98食物频率问卷。黄酮类化合物的摄入量是从美国农业部黄酮类化合物数据库中估算的，这些数据库最近进行了改进，以解决熟食的缺失值，并调整由于加工造成的黄酮类化合物损失。CHD事件由参与者报告并由专家裁定。采用考克斯比例风险回归分析方法，对类黄酮摄入量的五分位数作为冠心病发病的预测因子进行了检验，以获得HR。结果：在平均+/- SD随访6.0 +/- 1.9年的时间里，发生了589例CHD事件。高类黄酮摄入量与自我认定的白色种族、锻炼、不吸烟、更多的教育和更高的收入有关。在调整了社会人口统计学、健康行为和饮食因素的模型中，花青素和原花青素摄入量与冠心病发病率呈负相关（五分位数5与五分位数1相比的HR-花青素：0.71; 95% CI：0.52，0.98; P-趋势= 0.04;原花青素：0.63; 95% CI：0.47，0.84; P趋势= 0.02）。总黄酮或其他类黄酮摄入量与冠心病发病率之间无相关性。结论：报道的花青素和原花青素摄入量与冠心病发病率呈负相关。年龄、性别、种族或居住地区没有显着影响。
Background: Flavonoids are dietary polyphenolic compounds with a variety of proposed beneficial cardiovascular effects, but rigorous prospective studies that examine the association between flavonoid intake and incident coronary heart disease (CHD) in geographically and racially diverse US samples are limited.Objective: With the use of the new, expanded USDA flavonoid database, we assessed the association between total flavonoid and flavonoid subclass intakes with incident CHD in a biracial and geographically diverse cohort, as well as effect modification by age, sex, race, and region of residence.Design: Participants were 16,678 black and white men and women enrolled in the REGARDS (REasons for Geographic and Racial Differences in Stroke) study, a national prospective cohort study. All participants were without CHD at baseline, and all completed a Block98 food-frequency questionnaire. Flavonoid intakes were estimated from USDA flavonoid databases, which were recently improved to address missing values for cooked foods and to adjust for flavonoid losses due to processing. Incident CHD events were participant reported and adjudicated by experts. Quintiles of flavonoid intake were examined as predictors of incident CHD by using Cox proportional hazards regression to obtain HRs. Tests for trend used the quintile medians.Results: Over a mean +/- SD follow-up of 6.0 +/- 1.9 y, 589 CHD events occurred. High flavonoid intake was associated with self identified white race, exercise, not smoking, more education, and higher income. In models that adjusted for sociodemographic, health behavior, and dietary factors, there was an inverse association between anthocyanidin and proanthocyanidin intakes and incident CHD (HRs for quintile 5 compared with quintile 1-anthocyanidins: 0.71; 95% CI: 0.52, 0.98; P-trend = 0.04; proanthocyanidins: 0.63; 95% CI: 0.47, 0.84; P-trend = 0.02). There was no association between total flavonoid or other flavonoid subclass intakes and incident CHD.Conclusions: Reported anthocyanidin and proanthocyanidin intakes were inversely associated with incident CHD. There was no significant effect modification by age, sex, race, or region of residence.