Identification of hippocampus-related candidate genes for Alzheimer's disease
Identification of hippocampus-related candidate genes for Alzheimer's disease
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DOI：
10.1002/ana.20433
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发表时间：
2005-04-01
影响因子：
11.2
通讯作者：
Miki, T
中科院分区：
文献类型：
--
作者：
Taguchi, K;Yamagata, HD;Miki, T
阿尔茨海默病（Alzheimer's disease，AD）是一种复杂的多因素疾病，涉及多种遗传和环境因素。我们对376例AD患者和376例对照组进行了相关性研究。我们研究了35个基因的35个单核苷酸多态性，与对照组相比，这些基因仅在AD海马中显著下调或上调，发现9个单核苷酸多态性与AD相关。我们的数据表明单核苷酸多态性可以高度反映基因表达的差异。此外，内含子多态性。POU 2F 1中的T/C（+9943 T/C）与AD最显著相关（p = 0.0007）。我们的研究结果表明POU 2F 1是AD的候选基因。
Alzheimer's disease (AD) is a complex multifactorial disease in which many genetic and environmental factors are involved. We performed an association study using 376 AD patients and 376 control subjects. We studied 35 single nucleotide polymorphisms in 35 genes that were significantly downregulated or upregulated only in the AD hippocampus compared with control and found that 9 single nucleotide polymorphisms were associated with AD. Our data indicated that single nucleotide polymorphisms could highly reflect differences in gene expression. Furthermore, an intronic polymorphism. (+9943T/C) in POU2F1 was most significantly associated with AD (p = 0.0007). Our results suggest that POU2F1 is a candidate gene for AD.