Reading disorders in primary progressive aphasia: A behavioral and neuroimaging study
Reading disorders in primary progressive aphasia: A behavioral and neuroimaging study
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DOI：
10.1016/j.neuropsychologia.2009.02.033
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发表时间：
2009-07-01
期刊：
影响因子：
2.6
通讯作者：
Gorno-Tempini, M. L.
中科院分区：
文献类型：
--
作者：
Brambati, S. M.;Ogar, J.;Gorno-Tempini, M. L.
以往对获得性阅读障碍的神经心理学研究揭示了阅读障碍的双重分离。语音阅读障碍患者在阅读假词时存在选择性困难，而表面阅读障碍患者则误读了例外词。这种阅读能力的双重分离经常被报道在脑损伤患者中，但它并没有被一致地显示在神经退行性疾病患者中。在这项研究中，我们调查了各种神经退行性疾病的阅读障碍及其解剖学相关性。首先，我们进行了行为分析，以表征不同的词类型的原发性进行性失语症（PPA）的阅读。然后，我们进行了基于体素的形态计量学神经影像学研究，以映射大脑区域的灰质体积与异常和伪词的准确阅读的相关性，结果显示异常和伪词的阅读能力在不同的PPA的临床变异的差异模式。语义性痴呆，一种障碍的特点是选择性丧失的语义记忆，揭示了一种模式的表面阅读障碍，而患者与标识penic/语音进行性失语症，定义为语音环路缺陷，表现出语音阅读障碍。神经影像学结果显示，异常词阅读准确率与左前颞叶结构（包括颞极、颞中前上回和梭状回）的灰质体积相关，而伪词阅读准确率与左颞顶区域（包括颞中后上级回和梭状回）相关，这些结果表明，异常和伪词阅读不仅依赖于不同的语言机制选择性地损害PPA，但这些过程是由不同的大脑结构维持。(C)2009爱思唯尔有限公司保留所有权利。
Previous neuropsychological studies on acquired dyslexia revealed a double dissociation in reading impairments. Patients with phonological dyslexia have selective difficulty in reading pseudo-words, while those with surface dyslexia misread exception words. This double dissociation in reading abilities has often been reported in brain-damaged patients, but it has not been consistently shown in patients with neurodegenerative diseases.In this study, we investigated reading impairments and their anatomical correlates in various neurodegenerative diseases. First, we performed a behavioral analysis to characterize the reading of different word types in primary progressive aphasia (PPA). Then, we conducted a voxel-based morphometry neuroimaging study to map the brain areas in which gray matter volume correlated with the accurate reading of exception and pseudo-words.The results showed a differential pattern of exception and pseudo-word reading abilities in different clinical variants of PPA. Patients with semantic dementia, a disorder characterized by selective loss of semantic memory, revealed a pattern of surface dyslexia, while patients with logo penic/phonological progressive aphasia, defined by phonological loop deficits, showed phonological dyslexia. Neuroimaging results showed that exception word reading accuracy correlated with gray matter volume in the left anterior temporal structures, including the temporal pole, the anterior superior and middle temporal and fusiform gyri, while pseudo-word reading accuracy correlated with left temporoparietal regions, including the posterior superior and middle temporal and fusiform gyri, and the inferior parietal lobule.These results suggest that exception and pseudo-word reading not only rely upon different language mechanisms selectively damaged in PPA, but also that these processes are sustained by separate brain structures. (C) 2009 Elsevier Ltd. All rights reserved.