Direct Ventral Hippocampal-Prefrontal Input Is Required for Anxiety-Related Neural Activity and Behavior.
Direct Ventral Hippocampal-Prefrontal Input Is Required for Anxiety-Related Neural Activity and Behavior.
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DOI：
10.1016/j.neuron.2016.01.011
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发表时间：
2016-02-17
期刊：
影响因子：
16.2
通讯作者：
Gordon JA
中科院分区：
文献类型：
--
作者：
Padilla-Coreano N;Bolkan SS;Pierce GM;Blackman DR;Hardin WD;Garcia-Garcia AL;Spellman TJ;Gordon JA
腹侧海马区(VHPC)、内侧前额叶皮质(MPFC)和基底外侧杏仁核(BLA)都是焦虑样行为表达所必需的。然而，电路中每个单独元素的作用尚不清楚。从vHPC到mPFC的投射与焦虑相关的神经同步性和厌恶的空间表征有关。这种投射的作用是用多点神经记录结合光遗传终末抑制来检验的。抑制vHPC对mPFC的输入扰乱了焦虑和mPFC对厌恶的表征，并以路径、频率和任务特定的方式降低了theta同步性。此外，双侧而不是单侧抑制改变了BLA中焦虑的生理相关性，模拟了一种类似安全的状态。这些结果揭示了vHPC-mPFC投射在焦虑相关行为和mPFC中厌恶信息的空间表征中的特定作用。
The ventral hippocampus (vHPC), medial prefrontal cortex (mPFC), and basolateral amygdala (BLA) are each required for the expression of anxiety-like behavior. Yet the role of each individual element of the circuit is unclear. The projection from the vHPC to the mPFC has been implicated in anxiety-related neural synchrony and spatial representations of aversion. The role of this projection was examined using multi-site neural recordings combined with optogenetic terminal inhibition. Inhibition of vHPC input to the mPFC disrupted anxiety and mPFC representations of aversion, and reduced theta synchrony in a pathway-, frequency- and task-specific manner. Moreover, bilateral, but not unilateral inhibition altered physiological correlates of anxiety in the BLA, mimicking a safety-like state. These results reveal a specific role for the vHPC-mPFC projection in anxiety-related behavior and the spatial representation of aversive information within the mPFC.