Association of iron metabolic enzyme hepcidin expression levels with the prognosis of patients with pancreatic cancer
Association of iron metabolic enzyme hepcidin expression levels with the prognosis of patients with pancreatic cancer
复制标题
DOI：
10.3892/ol.2018.8357
复制
发表时间：
2018-05-01
期刊：
影响因子：
2.9
通讯作者：
Ishii, Hideshi
中科院分区：
文献类型：
--
作者：
Toshiyama, Reishi;Konno, Masamitsu;Ishii, Hideshi
作为关键的铁调节剂，海普西丁和铁蛋白可能会被用于未来胰腺导管腺癌的治疗。铁对生命维持是必不可少的；它帮助氧分子与血红蛋白结合，并充当重要的催化酶中心。然而，铁超载是癌症的危险因素，可能是通过产生活性氧物种(ROS)来实现的。海普西丁是一种主要由肝脏产生的多肽激素，它抑制肠细胞对铁的吸收和巨噬细胞释放铁。值得注意的是，海普西丁通过调节铁转运蛋白来调节体内的铁稳态。在目前的研究中，假设高表达的海普西丁和低表达的铁蛋白导致恶性。因此，研究海普西丁和铁门蛋白的表达水平是否与胰腺癌患者的预后相关。结果显示，胰腺癌组织中海普西丁的高表达和铁孔蛋白的低表达与总体生存分析中的预后不良显著相关(P分别为0.0140和0.0478)。此外，海普西丁和铁孔蛋白染色组的无病存活率没有显著差异。海普西丁的表达与肿瘤的病理分期和血管侵犯有关(P=0.0493和0.0400)，铁门蛋白的表达与年龄有关(P=0.0372)。多因素分析显示病理N因子(PN)、辅助化疗和表达是独立的预后因素(P值分别为0.0450、0.0002和0.0049)。同样，铁孔蛋白染色组总生存期的多因素分析显示，血管侵犯和铁孔蛋白表达是独立的预后因素(P=0.0028，P
Hepcidin and ferroportin, which are known as key iron regulators, may be used in future treatments of pancreatic ductal adenocarcinoma. Iron is essential for life support; it helps oxygen molecules bind to hemoglobin and acts as an important catalytic enzyme center. However, iron overload is a risk factor for cancer, possibly through the generation of reactive oxygen species (ROS). Hepcidin, which is a peptide hormone mainly generated by the liver, inhibits iron absorption via enterocytes and iron release from macrophages. Notably, hepcidin regulates iron homeostasis in the body by regulating the iron transporter ferroportin. In the present study, it was assumed that high hepcidin expression and low ferroportin expression result in malignancy. Therefore, it was examined whether hepcidin and ferroportin expression levels were correlated with the prognosis of pancreatic cancer in patients. Results revealed that high hepcidin expression levels and low ferroportin expression levels in pancreatic cancer tissue were significantly associated with poor prognosis in the analyses of overall survival (P=0.0140 and 0.0478, respectively). Additionally, there was no significant difference in disease-free survival in the hepcidin-and ferroportin-staining groups. Hepcidin expression correlated with the pathological stage and vascular invasion (P=0.0493 and 0.0400, respectively), and ferroportin expression was correlated with age (P=0.0372). Multivariate analysis of overall survival in the hepcidin-staining group revealed that pathological N factor (pN), adjuvant chemotherapy, and hepcidin expression were independent prognostic factors (P=0.0450, 0.0002, and 0.0049, respectively). Similarly, multivariate analysis of overall survival in the ferroportin-staining group revealed that vascular invasion, and ferroportin expression were independent prognostic factors (P=0.0028, P