Compounds from Arnebia euchroma and Their Related Anti-HCV and Antibacterial Activities
Compounds from Arnebia euchroma and Their Related Anti-HCV and Antibacterial Activities
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紫草化合物及其相关的抗 HCV 和抗菌活性
DOI：
10.1055/s-0031-1280266
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发表时间：
2012-01-01
期刊：
影响因子：
2.7
通讯作者：
Xia, Xue-Shan
中科院分区：
文献类型：
--
作者：
Li, Hong-Mei;Tang, Ying-Lei;Xia, Xue-Shan
从新疆紫草（ARNEBIA EUCHROMA）的茎皮中分离得到3个新的苯并对苯二酚萜类化合物：Euchroquinols A-C（1- 3）和一个新的单萜基苯型化合物：9，17-环氧芳醇（4），沿着5个已知化合物。紫草素（6）显示出较强的抗HCV活性，选择性指数为43.56;化合物1、6和脱-O-甲基毛蕊异黄酮（7）显示出较强的抗金黄色葡萄球菌活性，MIC分别为0.5、0.125和0.125 mg/mL。
Three new hydroquinone terpenoids with benzogeijerene skeletons, euchroquinols A-C (1- 3), and a new monoterpenylbenzenoid, 9,17-epoxyarnebinol (4), along with five known compounds were isolated from the stem bark of ARNEBIA EUCHROMA. Shikonin (6) exhibited potent anti-HCV activity with a selective index of 43.56, and compounds 1, 6, and des-O-methyllasiodiplodin (7) showed anti-Staphylococcus aureus activity with MICs of 0.5, 0.125, and 0.125 mg/mL, respectively.