Antibacterial Activity of Polymers: Discussions on the Nature of Amphiphilic Balance
Antibacterial Activity of Polymers: Discussions on the Nature of Amphiphilic Balance
复制标题
聚合物的抗菌活性：两亲平衡性质的讨论
DOI：
10.1002/ange.201813810
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发表时间：
2019
影响因子：
--
通讯作者：
Ragogna, Paul J.
中科院分区：
文献类型：
--
作者：
Palermo, Edmund F.;Lienkamp, Karen;Gillies, Elizabeth R.;Ragogna, Paul J.
本观点的目的是讨论指导合成抗菌聚合物开发的分子设计原则，特别是旨在模拟宿主防御肽（HDPs）结构的分子设计原则。特别是，我们专注于“两亲性平衡”的原则，因为它涉及到一些最近开发的聚膦有点非典型结构。我们发现，两亲性平衡的基本概念仍然适用于这些新的聚合物，但实现这种平衡的方法有些独特。然后，我们简要概述了这一领域未来的挑战和机遇。
The purpose of this Viewpoint is to discuss the molecular design principles that guide development of synthetic antimicrobial polymers, especially those intended to mimic the structure of host defense peptides (HDPs). In particular, we focus on the principle of “amphiphilic balance” as it relates to some recently developed polyphosphoniums with somewhat atypical structure. We find that the fundamental concept of amphiphilic balance is still applicable to these new polymers, but that the method to achieve such balance is somewhat unique. We then briefly outline the future challenges and opportunities in this field.