Effects of lead and cadmium co-exposure on bone mineral density in a Chinese population
Effects of lead and cadmium co-exposure on bone mineral density in a Chinese population
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DOI：
10.1016/j.bone.2014.02.017
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发表时间：
2014-06-01
期刊：
影响因子：
4.1
通讯作者：
Zhu, Guoying
中科院分区：
文献类型：
--
作者：
Chen, Xiao;Wang, Keyue;Zhu, Guoying
研究表明，镉（Cd）和铅（Pb）都可能对骨骼产生不利影响。然而，大多数研究只关注单一因素。本研究观察了 Cd 和 Pb 对中国人群骨密度 (BMD) 的主要影响和交互影响。共有 321 名居住在对照区和污染区的年龄 27 岁及以上的个体（202 名女性和 119 名男性）被招募参加这项研究。通过双能 X 射线骨密度仪 (DXA) 测量桡骨和尺骨近端的 BMD。采集尿液和血液样本，测定尿液（UCd和UPb）和血液（BCd和BPb）中Cd和Pb的水平。污染区居民的Cd和Pb水平显着高于对照区（p < 0.05）。污染区女性的BMD 显着低于对照区女性（p < 0.05）。此外，女性的 BMD 随着 BCd (p < 0.05)、BPb 和 UPb 的增加而降低。低 BMD 的可能性与女性较高的 BCd（OR = 2.5，95% CI：1.11-5.43）和男性较高的 BPb（OR = 4.49，95% CI：1.37-14.6）相关。 BCd 和 BPb 水平较高的女性和男性受试者的低 BMD 相对额外风险指数分别为 0.45 和 1.16。这项研究强化了先前的证据，即镉和铅可能影响骨骼，并且还证明镉和铅可能对 BMD 产生交互作用。 (C) 2014 爱思唯尔公司保留所有权利。
It has been indicated that both cadmium (Cd) and lead (Pb) may have adverse effects on the bone. However, most studies have only focused on a single factor. The primary and main and interactive effects of Cd and Pb on bone mineral density (BMD) in a Chinese population were observed in this study. A total of 321 individuals (202 women and 119 men), aged 27 years and older, living in control and polluted areas, were recruited to participate in this study. The BMD was measured through dual energy X-ray absorptiometry (DXA) at the proximal radius and ulna. The samples of urine and blood were collected to determine the levels of Cd and Pb in the urine (UCd and UPb) and blood (BCd and BPb). The Cd and Pb levels of people living in the polluted area were significantly higher than those living in the control area (p < 0.05). The BMD of women living in polluted area was significantly lower than that of women living in the control area (p < 0.05). Furthermore, the BMD decreased with increasing of BCd (p < 0.05), BPb and UPb in women. The likelihood of low BMD was associated with higher BCd in women (OR = 2.5, 95% CI: 1.11-5.43) and BPb in men (OR = 4.49,95% CI: 1.37-14.6). The relative extra risk index of low BMD for female and male subjects with both high levels of BCd and BPb was 0.45 and 1.16, respectively. This study strengthens previous evidence that cadmium and lead may influence the bone and also demonstrates that cadmium and lead may have interactive effects on BMD. (C) 2014 Elsevier Inc All rights reserved.