Alterations in regional ventilation, perfusion, and shunt after smoke inhalation measured by PET.
Alterations in regional ventilation, perfusion, and shunt after smoke inhalation measured by PET.
复制标题
通过 PET 测量烟雾吸入后局部通气、灌注和分流的变化。
DOI：
10.1152/japplphysiol.00911.2001
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Venegas,JoseG
中科院分区：
文献类型：
--
作者：
Willey-Courand,DonnaBeth;Harris,RScott;Galletti,GaetanoG;Hales,CA;Fischman,Alan;Venegas,JoseG
Regional changes in ventilation and perfusion occurring in the early hours after smoke inhalation injury were evaluated through the use of positron emission tomography. Five lambs were imaged before and 1, 2, and 4 h after receiving 100 breaths of cotton smoke. Utilizing a recently developed model of13N tracer kinetics (3), we evaluated changes in ventilation, perfusion, shunt, and regional gas content in nondependent, middle, and dependent lung zones. The data demonstrated a progressive development of regional shunt in dependent (dorsal) regions in which perfusion remained the highest throughout the study. These findings, together with decreasing regional ventilation and fractional gas content in the dependent regions, correlated with decreasing arterial PaO2values over the course of the study. A negative correlation between regional shunt fraction and regional gas content in dependent and middle regions suggests that shunt was caused by progressive alveolar derecruitment or flooding.
