Circadian clocks: Neural and peripheral pacemakers that impact upon the cell division cycle
Circadian clocks: Neural and peripheral pacemakers that impact upon the cell division cycle
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DOI：
10.1016/j.mrfmmm.2005.01.024
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发表时间：
2005-07-01
影响因子：
2.3
通讯作者：
Hastings, MH
中科院分区：
文献类型：
--
作者：
Reddy, AB;Wong, GKY;Hastings, MH
昼夜节律钟是普遍存在的实体，允许生物体保持大约24小时的节律，独立于外部线索，从而使它们适应太阳周期。最近的研究表明，分子生物钟对于细胞分裂周期的正确编排是重要的。这是第一次，这提供了一个框架，以了解这两个进化相关的计时器之间的相互作用。在这里，我们回顾了目前的生物钟模型和分子方法，可以用来研究其功能。然后，我们在细胞水平上绘制出与细胞周期的联系。此外，我们回顾了最近的进展，已链接功能障碍的钟表机构与癌症的发病机制。因此，昼夜节律的紊乱（如时差反应、轮班工作和痴呆症）对细胞分裂的正常调节有着深远的影响。这对“24小时社会”的健康影响是显而易见的。(c)2005 Elsevier B.V.保留所有权利。
Circadian clocks are pervasive entities that allow organisms to maintain rhythms of approximately 24 h, independently of external cues, thereby adapting them to the solar cycle. Recent studies have shown that molecular circadian clocks are important for the proper orchestration of the cell division cycle. For the first time, this provides a framework to understand the interactions between these two evolutionarily linked timers. Here we review the current model of the circadian clock and the molecular methods that can be used to investigate its function. We then map out links to the cell cycle at the cellular level. Furthermore, we review recent progress that has linked dysfunction of the clockwork with the pathogenesis of cancer. Disruption of circadian timing (as occurs in jet-lag, shift work and dementia) thus has far reaching consequences for normal regulation of cell division. The implications of this for the health of a "24-h society" are apparent. (c) 2005 Elsevier B.V. All rights reserved.