Curcumin and its Formulations: Potential Anti-Cancer Agents
Curcumin and its Formulations: Potential Anti-Cancer Agents
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DOI：
10.2174/187152012800228733
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发表时间：
2012-03-01
影响因子：
2.8
通讯作者：
Zhu, Hai-Liang
中科院分区：
文献类型：
--
作者：
Ji, Jun-Ling;Huang, Xian-Feng;Zhu, Hai-Liang
姜黄素是从姜黄中提取的一种天然化合物，是目前研究最多的化学预防药物之一。近半个世纪以来的广泛研究表明，姜黄素可以抑制培养的各种肿瘤细胞的增殖，预防致癌物诱导的啮齿动物癌症，并在异种移植或原位移植动物模型中抑制人类肿瘤的生长。一些I期和II期临床试验表明姜黄素是相当安全的，可能表现出治疗效果。姜黄素的应用受到其缺乏水溶性和相对较低的体内生物利用度的限制。包括纳米颗粒、脂质体、胶束和磷脂复合物在内的多种方法正在寻求克服这些限制。本文综述了姜黄素的一般特性及其潜在的抗癌作用，包括其体外、体内和临床抗肿瘤作用的证据以及克服其低生物利用度的策略。
Curcumin, one of the most studied chemopreventive agents, is a natural compound extracted from Curcuma longa L. Extensive research over the last half century has revealed that curcumin can inhibit the proliferation of various tumor cells in culture, prevent carcinogen induced cancers in rodents and inhibit the growth of human tumors in xenotransplant or orthotransplant animal models. Several phase I and phase II clinical trials indicated that curcumin is quite safe and may exhibit therapeutic efficacy. The utility of curcumin is limited by its lack of water solubility and relatively low in vivo bioavailability. Multiple approaches including nanoparticles, liposomes, micelles and phospholipid complexes are being sought to overcome these limitations. This review describes the general properties of curcumin and its potential effect against cancer including evidences of its antitumor action in vitro, in vivo, clinically and the strategies to overcome its low bioavailability.