Serum vitamin B12 and homocysteine levels in pregnant women with neural tube defect
Serum vitamin B12 and homocysteine levels in pregnant women with neural tube defect
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DOI：
10.3109/09513591003632183
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发表时间：
2010-08-01
影响因子：
2
通讯作者：
Baser, Iskender
中科院分区：
文献类型：
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作者：
Ceyhan, Seyit T.;Beyan, Cengiz;Baser, Iskender
目标。本研究的目的是探讨血清维生素B12水平对胎儿神经管缺陷（NTD）孕妇的重要性。研究设计。本研究包括31名有NTD胎儿的孕妇。研究组的孕妇是从叶酸水平正常的孕妇中挑选出来的。研究了血清维生素B12水平。测定全血细胞计数、血清铁水平、铁结合能力、铁蛋白、叶酸、游离T-3、游离T-4、促甲状腺激素和血浆同型半胱氨酸水平。对照组由32名孕妇组成，她们在以前的妊娠中没有NTD病史，并且在这次妊娠中没有患NTD的胎儿。NTD在14至20胎龄之间被诊断出来。对照组成员的平均胎龄与NTD组相同。从维生素B12缺乏的例数来看，NTD孕妇与对照组的差异无统计学意义。似乎维生素B12缺乏并没有在胎儿NTD的发展中起导致作用。监测母体同型半胱氨酸水平对了解胎儿NTD的病因可能很重要。
Objective. The aim of the study is to investigate the importance of serum vitamin B12 levels in pregnant women with foetal neural tube defect (NTD).Study design. This study consists of 31 pregnant women having fetuses with NTD. The pregnant women in the study group were selected among cases with normal folate levels. Serum vitamin B12 levels were investigated. Additionally, complete blood count, serum iron level, iron binding capacity, ferritin, folate, free T-3, free T-4, thyroid stimulating hormone and plasma homocysteine levels were measured. Control group consisted of 32 pregnant women who did not have a history of NTD in previous pregnancies and did not have fetuses with NTD in present pregnancy. NTD was diagnosed between14th and 20th gestational age. The mean gestational age of members of control group was the same as those of NTD group.Results. There was no statistically significant difference between pregnants with NTD and control group according to number of cases with vitamin B12 deficiency.Conclusion. It seems that vitamin B12 deficiency does not play a causative role in the development of foetal NTD. Monitoring maternal homocystein levels might be important in understanding the aetiologies of foetal NTD.