[C-reactive protein as early marker of chorioamnionitis in premature rupture of membranes].
[C-reactive protein as early marker of chorioamnionitis in premature rupture of membranes].
复制标题
C反应蛋白作为胎膜早破绒毛膜羊膜炎的早期标志物
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
S. Karchmer
中科院分区：
文献类型：
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作者：
V. Ibarra Chavarría;P. Sanhueza Smith;M. Mota González;G. del Rey Pineda;S. Karchmer
本研究旨在探讨C反应蛋白（CRP）与其他感染指标的相关性，以了解其在早期诊断脉络膜炎中的准确性。对30例妊娠28 ~ 35周诊断为胎膜早破（PRM）的患者进行前瞻性研究，并与30例妊娠相似但无PRM、感染、自身免疫性疾病或慢性炎症的对照组进行比较。CRP值为2 mg/dl。研究组包括17例被认为是阳性的患者，13例阴性;感染妇女和未感染妇女的CRP值差异显著，概率小于0.001（Fisher），敏感性为94.12%，特异性为100%，阳性预测值为100%，阴性预测值为98.86%。目前的数据表明，CRP是羊膜感染的早期检测。
This study was done in order to correlate the C-Reactive Protein levels (CRP) determined by nephelometric technique, with other infection indicators, and to know its exactness in early detection of chorioamnioitis. Thirty patients were prospectively studied with pregnancies from 28 to 35 weeks of gestation with diagnosis of premature rupture of membranes (PRM); and were compared to control group (30 patients) with similar gestation without PRM, infection, autoimmune diseases or chronic inflammation. The value for CRP was 2 mg/dl. The study group included 17 patients considered as positive, and 13 negative; the differences in CRP values in infected women was significant and not infected ones with a probability less than 0.001 (Fisher), with a sensitivity of 94.12%, and specificity of 100% positive predictive value of 100%, and a negative predictive value of 98.86%. The present data show that CRP is an early detector of amniotic infection.