A receptor-targeting AIE photosensitizer for selective bacterial killing and real-time monitoring of photodynamic therapy outcome
A receptor-targeting AIE photosensitizer for selective bacterial killing and real-time monitoring of photodynamic therapy outcome
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DOI：
10.1039/d2cc02230c
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发表时间：
2022-05-20
影响因子：
4.9
通讯作者：
Zhu, Chunlei
中科院分区：
文献类型：
--
作者：
Wang, Cheng;Wang, Jiaxin;Zhu, Chunlei
通过将头孢噻吩与阳离子D-A型AIE光敏剂偶联，合成了受体靶向AIE光敏剂（CE-TPA），用于选择性杀死革兰氏阳性菌而不是革兰氏阴性菌和正常哺乳动物细胞。CE-TPA具有较强的光敏能力，对革兰氏阳性耐甲氧西林金黄色葡萄球菌具有高效杀伤作用。更重要的是，CE-TPA的偏振敏感特性可以方便地实时反映光动力杀菌效果。
A receptor-targeting AIE photosensitizer (CE-TPA) is synthesized by conjugating cephalothin with a cationic D-A type AIE photosensitizer for selective killing of Gram-positive bacteria over Gram-negative bacteria and normal mammalian cells. By virtue of the strong photosensitization capability, CE-TPA exhibits efficient killing against Gram-positive methicillin-resistant Staphylococcus aureus. More importantly, the photodynamic bactericidal outcome can be conveniently reflected in a real-time fashion by the polarity-sensitive property of CE-TPA.