HEPATIC CLEARANCE OF SALMONELLA-TYPHIMURIUM IN SILICA-TREATED MICE
HEPATIC CLEARANCE OF SALMONELLA-TYPHIMURIUM IN SILICA-TREATED MICE
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DOI：
10.1128/iai.16.3.1005-1012.1977
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发表时间：
1977-01-01
影响因子：
3.1
通讯作者：
MOON, RJ
中科院分区：
文献类型：
--
作者：
FRIEDMAN, RL;MOON, RJ
扫描电镜显示结晶二氧化硅破坏肝库普弗细胞，但对肝脏没有其他明显的有害影响。二氧化硅处理的肝脏仍然保留了捕获大量通过门静脉灌注的细菌的能力，即使清除率远低于正常水平。在体内，二氧化硅处理降低了血液中细菌的清除率，改变了被清除细菌在体内的器官分布，使鼠伤寒沙门氏菌的平均致死剂量降低了100倍以上。总的来说，数据表明二氧化硅处理增强了对革兰氏阴性感染的易感性，可能是通过破坏巨噬细胞。
Scanning electron microscopy demonstrates that crystalline silica destroys liver Kupffer cells but has no other obvious deleterious effects on the liver. Silica-treated livers still retain the ability to trap large numbers of bacteria perfused through the portal vein even though the rate of clearance is well below normal. In vivo, silica treatment decreases the rate of bacterial clearance from the blood, alters the in vivo organ distribution of cleared bacteria and decreases the mean lethal dose of S. typhimurium over 100-fold. Cumulatively, the data indicate that silica treatment enhances susceptibility to gram-negative infection, probably by destruction of macrophages.