Increased serum levels of B cell activating factor (BAFF) in subsets of patients with idiopathic inflammatory myopathies
Increased serum levels of B cell activating factor (BAFF) in subsets of patients with idiopathic inflammatory myopathies
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DOI：
10.1136/ard.2008.091405
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发表时间：
2009-06-01
影响因子：
27.4
通讯作者：
Lundberg, I. E.
中科院分区：
文献类型：
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作者：
Krystufkova, O.;Vallerskog, T.;Lundberg, I. E.
目的：探讨肌炎患者血清中B细胞活化因子(BAFF)的水平及其与自身抗体谱、临床表型和治疗的关系。方法：采用双抗体夹心EL ISA法检测49例皮肌炎、44例多发性肌炎、6例包涵体肌炎和30例正常对照血清中的BAFF水平。结果：患者血清BAFF水平明显高于健康对照组(p=0.003)。具有抗Jo-1自身抗体的患者的BAFF水平高于对照组(P<；0.003)或没有任何特定自身抗体的患者(P<；0.05)。皮肌炎患者的BAFF水平高于多发性肌炎患者(p<；0.05)。间质性肺病(ILD)患者的BAFF水平高于非ILD患者(P<；0.05)或对照组(P<；0.01)，但这可以用抗Jo-1自身抗体的存在来解释。BAFF水平与血清肌酸激酶(CK)水平相关(rS=0.365，p=0.0005)，但与C反应蛋白水平无关。所有患者的血清bAFF水平与糖皮质激素日剂量呈负相关(rS=20.292，p=0.003)，与早期肌炎患者的累积糖皮质激素剂量呈负相关(rS=20.659，p<；0.001)。结论：我们的研究结果表明，在具有上述表型的肌炎患者中，bAFF水平升高，bAFF和CK水平之间的相关性以及与糖皮质激素剂量的负相关表明，bAFF可能是此类病例的潜在治疗靶点。
Objective: To investigate serum levels of B cell activating factor (BAFF) in patients with myositis and correlate these to autoantibody profile, clinical phenotype and treatment.Methods: BAFF levels in sera from 49 patients with dermatomyositis, 44 with polymyositis, 6 with inclusion body myositis and 30 matched controls were measured by ELISA. Specific autoantibodies were detected by line blot and western blot assays.Results: Serum levels of BAFF were significantly higher in patients compared to healthy controls (p = 0.003). Patients with anti-Jo-1 autoantibodies had higher BAFF levels than control individuals (p < 0.003) or patients without any specific autoantibodies (p < 0.05). Patients with dermatomyositis had higher BAFF levels compared to polymyositis (p < 0.05). Patients with interstitial lung disease (ILD) had higher BAFF levels than patients without ILD (p < 0.05) or controls (p < 0.01) but this could be explained by presence of anti-Jo-1 autoantibodies. BAFF levels correlated with serum creatine kinase (CK) (rs = 0.365, p = 0.0005) but not with C-reactive protein (CRP) levels. A negative correlation of BAFF levels with glucocorticoid daily dose for all patients (rs = 20.292, p= 0.003) and with cumulative glucocorticoid doses in early myositis cases (rs = 20.659, p < 0.001) was recorded.Conclusion: Our finding of elevated serum levels of BAFF in patients with myositis with described phenotypes together with the correlations between levels of BAFF and CK and a negative correlation with dose of glucocorticoids, indicate that BAFF could be a potential therapeutic target in such cases.