Facile Spray-Drying Assembly of Uniform Microencapsulates with Tunable Core-Shell Structures and Controlled Release Properties
Facile Spray-Drying Assembly of Uniform Microencapsulates with Tunable Core-Shell Structures and Controlled Release Properties
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DOI：
10.1021/la203249v
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发表时间：
2011-11-01
期刊：
影响因子：
3.9
通讯作者：
Chen, Xiao Dong
中科院分区：
文献类型：
--
作者：
Liu, Wenjie;Wu, Winston Duo;Chen, Xiao Dong
具有定义内核外壳结构的微封装对于控制释放和封装等应用很有意义，因为可以对不同部分的单个功能进行微调。在这里，我们报告了一种高效和可扩展生产这种粒子的新方法。以Eudragit RS（丙烯酸乙酯、甲基丙烯酸甲酯和低含量的季铵基甲基丙烯酸酯的共聚物）为主要外壳组分，二氧化硅为核心组分，通过一步喷雾干燥组装而成。该方法能够在不使用任何有机溶剂的情况下从均质前体形成均匀的核壳颗粒。在干燥过程中，蒸发诱导的自组装实现了不同组分之间的相分离，形成了核壳的空间构型，同时通过微流体喷射干燥器实现了对颗粒均匀性的精确控制。通过前驱体中核壳成分的比例可以实现对壳层厚度的直接控制。一种荧光化合物罗丹明B被用作高水溶性模型组分来研究这些微胶囊的控释特性，其释放行为显示出显著依赖于它们的结构。
Microencapsulates with defined core shell structures are of interest for applications, such as controlled release and encapsulation, because of the feasibility of fine-tuning individual functionalities of different parts. Here, we report a new approach for efficient and scalable production of such particles. Eudragit RS (a co-polymer of ethyl acrylate, methyl methacrylate, and a low content of methacrylic acid ester with quaternary ammonium groups) was used as the main shell component, with silica as the core component, formed upon a single-step spray-drying assembly. The method is capable of forming uniform core shell particles from homogeneous precursors without the use of any organic solvents. Evaporation-induced self-assembly attained the phase separation among different components during drying, resulting in the core shell spatial configuration, while precise control over particle uniformity was accomplished via a microfluidic jet spray dryer. Direct control over shell thickness can be achieved from the ratio of the core and shell ingredients in the precursors. A fluorescent compound, rhodamine B, is used as a highly water-soluble model component to investigate the controlled release properties of these microencapsulates, with the release behaviors shown to be significantly dependent upon their architectures.