Lower prefrontal activity in adults with obsessive-compulsive disorder as measured by near-infrared spectroscopy
Lower prefrontal activity in adults with obsessive-compulsive disorder as measured by near-infrared spectroscopy
复制标题
DOI：
10.1016/j.pnpbp.2012.11.013
复制
发表时间：
2013-06-03
影响因子：
5.6
通讯作者：
Kishimoto, Toshifumi
中科院分区：
文献类型：
--
作者：
Okada, Koji;Ota, Toyosaku;Kishimoto, Toshifumi
近红外光谱（NIRS）的最新发展使精神疾病的神经生物学基础的非侵入性阐明成为可能。人类患者的功能性神经影像学研究表明，额叶皮层和皮层下结构可能在强迫症（OCD）的病理生理中发挥作用。在这里，我们使用近红外光谱研究了12名强迫症患者和12名年龄和性别匹配的健康对照者的神经生物学功能。在Stroop色字任务中，使用24通道近红外光谱（NIRS）每0.1 s用前额叶探针测量一次血红蛋白（oxy-Hb）的相对浓度。OCD组前额叶皮层的Oxy-Hb变化明显小于对照组，尤其是左侧前额叶皮层。这些结果表明强迫症患者通过近红外光谱测量前额叶血流动力学反应降低。(c) 2012 Elsevier Inc.版权所有。
Recent developments in near-infrared spectroscopy (NIRS) have enabled the non-invasive elucidation of the neurobiological underpinnings of psychiatric disorders. Functional neuroimaging studies in human patients have suggested that the frontal cortex and subcortical structures may play a role in the pathophysiology of obsessive-compulsive disorder (OCD). Here we used NIRS to investigate neurobiological function in 12 patients with OCD and 12 age- and sex-matched, healthy control subjects. The relative concentrations of oxyhemoglobin (oxy-Hb) were measured with prefrontal probes every 0.1 s, during performance of a Stroop color-word task, using 24-channel NIRS. Oxy-Hb changes in the prefrontal cortex of the OCD group were significantly smaller than those in the control group, especially in the left lateral prefrontal cortex. These results suggest that patients with OCD have reduced prefrontal hemodynamic responses as measured by NIRS. (c) 2012 Elsevier Inc. All rights reserved.