CISAPRIDE ACCELERATES GASTRIC-EMPTYING AND MOUTH-TO-CAECUM TRANSIT OF A BARIUM MEAL
CISAPRIDE ACCELERATES GASTRIC-EMPTYING AND MOUTH-TO-CAECUM TRANSIT OF A BARIUM MEAL
复制标题
DOI：
10.1007/bf00542167
复制
发表时间：
1984-01-01
影响因子：
2.9
通讯作者：
VERLINDEN, M
中科院分区：
文献类型：
--
作者：
BAEYENS, R;REYNTJENS, A;VERLINDEN, M
西沙必利（r51 619）是一种新合成的化合物，可促进肠肌丛中乙酰胆碱的释放。在随机双盲条件下，84例患者评估了其对钡餐胃排空的影响。两种口服剂量（5mg和10mg）的西沙必利与安慰剂比较，两种静脉注射剂量（4mg和8mg）的西沙必利与安慰剂和10mg的甲氧氯普胺比较。所有剂量的西沙必利和甲氧氯普胺在加速胃排空、强化胃窦收缩和缩短口至盲肠转运时间方面均显著优于安慰剂。西沙必利8mg与甲氧氯普胺10mg静脉注射效果相当。
Cisapride (R 51 619) is a newly synthesized compound, which facilitates the release of acetylcholine in the myentric plexus of the gut. Its effect on gastric emptying of a barium meal was evaluated in 84 patients under randomized, double-blind conditions. Two oral doses (5 mg and 10 mg) of cisapride were compared with a placebo, and 2 i.v. doses (4 mg and 8 mg) with a placebo and with 10 mg metoclopramide. All doses of cisapride and metoclopramide were significantly superior to placebo in accelerating gastric emptying, intensifying antral contractions and shortening the mouth-to-caecum transit time. The effects of 8 mg cisapride and 10 mg metoclopramide give i.v. were comparable.