XPC: its product and biological roles.
XPC: its product and biological roles.
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DOI：
10.1007/978-0-387-09599-8_6
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发表时间：
2008
影响因子：
--
通讯作者：
K. Sugasawa
中科院分区：
文献类型：
--
作者：
K. Sugasawa
XPC蛋白是异源三聚体复合物的组分，其对于在整个基因组中操作的核苷酸切除修复子途径中的损伤识别是必需的。生化分析表明，这种修复系统的广泛底物特异性是基于XPC复合物的结构特异性DNA结合特性。该复合物的其他亚基，包括人Rad23p直系同源物和中心蛋白2，在增强XPC的损伤识别活性中发挥各自的作用。与UV损伤的DNA结合蛋白的物理相互作用对于XPC有效地募集到含有DNA损伤的位点，特别是UV诱导的光损伤也是重要的。此外，最近的研究表明，XPC也可能参与碱基切除修复，并可能在其他细胞功能，可能是由翻译后修饰介导的。
The XPC protein is a component of a heterotrimeric complex that is essential for damage recognition in a nucleotide excision repair subpathway that operates throughout the genome. Biochemical analyses have revealed that the broad substrate specificity of this repair system is based on the structure-specific DNA binding properties of the XPC complex. Other subunits of this complex, including human Rad23p orthologs and centrin 2, play individual roles in enhancing the damage recognition activity of XPC. Physical interaction with UV-damaged DNA-binding protein is also important for the efficient recruitment of XPC to sites containing DNA damage, particularly UV-induced photolesions. Furthermore, recent studies have suggested that XPC may also be involved in base excision repair and possibly in other cellular functions that may be mediated by posttranslational modifications.