Effects of Replication and Transcription on DNA Structure-Related Genetic Instability.
Effects of Replication and Transcription on DNA Structure-Related Genetic Instability.
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DOI：
10.3390/genes8010017
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发表时间：
2017-01-05
期刊：
影响因子：
3.5
通讯作者：
Vasquez KM
中科院分区：
文献类型：
--
作者：
Wang G;Vasquez KM
人类基因组中的许多重复序列可以采用不同于典型B-DNA双螺旋的构象（即，非B DNA），并且可以影响重要的生物过程，例如DNA复制、转录、重组、端粒维持、病毒整合、转座体激活、DNA损伤和修复。因此，非B DNA形成序列与遗传不稳定性和疾病发展有关。在这篇文章中，我们讨论了非B DNA与复制和/或转录机制的相互作用，特别是在疾病状态下（例如，肿瘤）可能导致异常的细胞环境，以及这种相互作用如何改变DNA复制和转录，导致非B DNA区域的潜在冲突，并最终导致遗传稳定性和人类疾病。
Many repetitive sequences in the human genome can adopt conformations that differ from the canonical B-DNA double helix (i.e., non-B DNA), and can impact important biological processes such as DNA replication, transcription, recombination, telomere maintenance, viral integration, transposome activation, DNA damage and repair. Thus, non-B DNA-forming sequences have been implicated in genetic instability and disease development. In this article, we discuss the interactions of non-B DNA with the replication and/or transcription machinery, particularly in disease states (e.g., tumors) that can lead to an abnormal cellular environment, and how such interactions may alter DNA replication and transcription, leading to potential conflicts at non-B DNA regions, and eventually result in genetic stability and human disease.