Aging, inflammation, stem cells, and bone healing.
Aging, inflammation, stem cells, and bone healing.
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DOI：
10.1186/s13287-016-0300-9
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发表时间：
2016-03-22
影响因子：
7.5
通讯作者：
Goodman SB
中科院分区：
文献类型：
--
作者：
Gibon E;Lu L;Goodman SB
单核细胞-巨噬细胞-破骨细胞谱系和间充质干细胞-成骨细胞谱系之间复杂的相互作用在骨愈合的病理生理中发挥重要作用。前者谱系指导炎症事件和骨吸收，后者代表骨再生和免疫调节的细胞来源。这两种谱系都受到年龄增长的影响，这与炎症介质的基线水平升高和成骨能力显著降低有关。综上所述，老年人骨折愈合、骨质疏松和其他相关事件面临着许多挑战，这些挑战可能会通过调节炎症和骨再生的新治疗方法得到帮助。
Complex interactions among cells of the monocyte-macrophage-osteoclast lineage and the mesenchymal stem cell-osteoblast lineage play a major role in the pathophysiology of bone healing. Whereas the former lineage directs inflammatory events and bone resorption, the latter represents a source of cells for bone regeneration and immune modulation. Both of these lineages are affected by increasing age, which is associated with higher baseline levels of inflammatory mediators, and a significant reduction in osteogenic capabilities. Given the above, fracture healing, osteoporosis, and other related events in the elderly present numerous challenges, which potentially could be aided by new therapeutic approaches to modulate both inflammation and bone regeneration.