Survivin in esophageal cancer: An accurate prognostic marker for squamous cell carcinoma but not adenocarcinoma
Survivin in esophageal cancer: An accurate prognostic marker for squamous cell carcinoma but not adenocarcinoma
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DOI：
10.1002/ijc.21923
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发表时间：
2006-10-01
影响因子：
6.4
通讯作者：
Zanovello, Paola
中科院分区：
文献类型：
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作者：
Rosato, Antonio;Pivetta, Michela;Zanovello, Paola
我们对112例食管癌(56例鳞癌和56例腺癌)标本中Survivin的表达进行了定量研究。Survivin mRNA高表达的鳞癌患者的总体生存率显著低于低Survivin mRNA表达的患者(p=0.0033)。Survivin的分布方式(核型、胞浆型或混合型)与生存期无关，而免疫染色程度与Survivin mRNA值显著相关(p=0.016)，单因素分析显示Survivin表达与预后相关(p=0.0012)。COX比例风险回归模型显示，Survivin在食管鳞癌中的表达是最重要的预后因素，与肿瘤分期和其他组织病理学因素无关，无论是表达相对值(p=0.0259)还是蛋白免疫染色(p=0.0147)。在食管腺癌中，Survivin的表达和分布方式与预后无关。因此，量化Survivin的表达只为食管鳞癌提供了一个预后标记物。(C)2006年Wiley-Liss，Inc.
We quantified the expression of survivin, both as mRNA in real-time PCR and protein in immunohistochemistry, in tumor samples of 112 patients with esophageal cancer (56 squamous cell carcinomas and 56 adenocarcinomas). Overall survival of squamous cell carcinoma patients with high survivin mRNA levels was significantly less than that of patients with low survivin mRNA levels (p = 0.0033). Distribution pattern of survivin (nuclear vs. cytoplasmic or mixed) was not correlated to survival, while the extent of immunostaining was significantly correlated to survivin mRNA values (p = 0.016) and had prognostic relevance in univariate analysis (p = 0.0012). Cox's proportional-hazard regression model showed that tumor survivin expression in esophageal squamous cell carcinoma was the most important prognostic factor, independent of tumor stage and other histopathological factors, both as mRNA relative value (p = 0.0259) and protein immunostaining (p = 0.0147). In esophageal adenocarcinoma, survivin expression and pattern of distribution had no prognostic relevance. Thus, quantifying survivin expression provides a prognostic marker only for esophageal squamous tumors. (c) 2006 Wiley-Liss, Inc.