Assembly, stability and integrity of basement membranes in vivo

Assembly, stability and integrity of basement membranes in vivo
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体内基底膜的组装、稳定性和完整性

DOI:
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发表时间:
2002
期刊:
The Histochemical Journal
影响因子:
--
通讯作者:
F. Quondamatteo
F. Quondamatteo
中科院分区:
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文献类型:
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作者:
F. Quondamatteo

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基底膜是将各种细胞与周围基质分开的细胞外基质的层状结构。关于基底膜经常出现的问题之一是这些结构在体内是如何形成的。直到几年前,人们还认为基底膜是通过其成分的自组装过程自发形成的。然而,现在已经清楚,基底膜成分的细胞膜受体是体内基底膜形成和稳定性的重要因素。本综述强调了基底膜形成的现代概念。
Basement membranes are layered structures of the extracellular matrix which separate cells of various kinds from the surrounding stroma. One of the frequently recurring questions about basement membranes is how these structures are formed in vivo. Up to a few years ago, it was thought that basement membranes were formed spontaneously by a process of self-assembly of their components. However, it has now become clear that cell membrane receptors for basement membrane components are essential factors for the formation and stability of basement membranes in vivo. The present review highlights the modern concepts of basement membrane formation.
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