Motor Modules are Impacted by the Number of Reaching Directions Included in the Analysis.
Motor Modules are Impacted by the Number of Reaching Directions Included in the Analysis.
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DOI：
10.1109/tnsre.2020.3008565
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发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
Krishnan C
中科院分区：
文献类型：
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作者：
Augenstein TE;Washabaugh EP;Remy CD;Krishnan C
肌肉协同分析通常用于研究神经系统如何在人类达到过程中协调大量肌肉的激活。在协同分析中，从各个到达方向收集的肌肉激活数据进行降维技术，以提取肌肉协同作用。通常，肌肉激活数据仅从有限的一组到达获得，其中固有的假设是，所执行的到达足以代表所有可能的到达。在这项研究中，我们研究了如何达到的方向，包括在协同分析的数量影响提取的协同效应的有效性。我们使用肌肉骨骼模型来计算执行36个均匀间隔的平面到达所需的肌肉激活。然后使用非负矩阵分解（NMF）和主成分分析（PCA）提取参比协同作用。然后，我们选择了几个子集的达到和比较的能力，从每个子集中提取的协同作用，以代表所有36个达到肌肉激活。我们发现，6达到提取有效的协同作用，并进一步减少达到的数量改变了所产生的协同作用的组成。此外，我们发现，选择的到达方向包括在分析中的给定数量的到达也影响了提取的协同效应的有效性。这些研究结果表明，分析中所包含的到达方向的数量和选择都会影响所提取的协同效应的有效性。
Muscle synergy analysis is commonly used to study how the nervous system coordinates the activation of a large number of muscles during human reaching. In synergy analysis, muscle activation data collected from various reaching directions are subjected to dimensionality reduction techniques to extract muscle synergies. Typically, muscle activation data are obtained only from a limited set of reaches with an inherent assumption that the performed reaches adequately represent all possible reaches. In this study, we investigated how the number of reaching directions included in the synergy analysis influences the validity of the extracted synergies. We used a musculoskeletal model to compute muscle activations required to perform 36 evenly spaced planar reaches. Nonnegative matrix factorization (NMF) and principal component analysis (PCA) were then used to extract reference synergies. We then selected several subsets of reaches and compared the ability of the extracted synergies from each subset to represent the muscle activation from all 36 reaches. We found that 6 reaches were required to extract valid synergies, and a further reduction in the number of reaches changed the composition of the resulting synergies. Further, we found that the choice of reaching directions included in the analysis for a given number of reaches also affected the validity of the extracted synergies. These findings indicate that both the number and the choice of reaching directions included in the analysis impacted the validity of the extracted synergies.