Triterpenoids of Ganoderma theaecolum and their hepatoprotective activities
Triterpenoids of Ganoderma theaecolum and their hepatoprotective activities
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DOI：
10.1016/j.fitote.2014.08.004
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发表时间：
2014-10-01
期刊：
影响因子：
3.4
通讯作者：
Chen, Ruo-Yun
中科院分区：
文献类型：
--
作者：
Liu, Li-Ying;Chen, Hui;Chen, Ruo-Yun
从茶灵芝（Ganoderma theaeclum）子实体中分离得到5个新的羊毛甾烷三萜类化合物，即灵芝酸XL 1（1）、灵芝酸XL 2（2）、20-羟基灵芝酸AM（1）（3）、灵芝烯酸AM（1）（4）和灵芝脂素C（5），以及5个已知三萜类化合物（6-10）。根据光谱学证据，包括1D，2D NMR，质谱数据和圆二色谱，鉴定了化学结构。化合物1、4、5、8、9和10（10 μ M）对DL-半乳糖胺诱导的HL-7702细胞损伤表现出肝保护活性。(C)© 2014 Elsevier B. V.保留所有权利。
Five new lanostane triterpenoids, ganoderic add XL1 (1), ganoderic acid XL2 (2), 20-hydroxy-ganoderic acid AM(1) (3), ganoderenic acid AM(1) (4) and ganoderesin C (5), together with five known triterpenoids (6-10) were isolated from the fruiting bodies of Ganoderma theaecolum. Chemical structures were elucidated on the basis of spectroscopic evidence, including 1D, 2D NMR, mass spectrometric data and circular dichroism spectra. Compounds 1, 4, 5, 8, 9 and 10 (10 mu M) exhibited hepatoprotective activities against DL-galactosamine-induced cell damage in HL-7702 cells. (C) 2014 Elsevier B.V. All rights reserved.