Effect of galanin on plasma glucose, insulin and pancreatic glucagon in dogs
Effect of galanin on plasma glucose, insulin and pancreatic glucagon in dogs
复制标题
DOI：
10.1177/147323000303100209
复制
发表时间：
2003-03-01
影响因子：
1.6
通讯作者：
Yoshimura, T
中科院分区：
文献类型：
--
作者：
Manabe, T;Okada, Y;Yoshimura, T
研究了合成甘丙肽对狗血糖、胰岛素和胰高血糖素水平的影响。输注甘丙肽可导致基础胰岛素水平迅速、可逆且呈剂量依赖性下降。当甘丙肽以4 μ g/kg/h的剂量给药时，观察到伴随胰岛素降低的血糖水平的最大增加。胰高血糖素水平与基础分泌相比变化不大。这些结果表明甘丙肽通过控制胰岛素分泌参与葡萄糖的调节。
The effect of synthetic galanin on plasma glucose, insulin and pancreatic glucagon levels in dogs was studied. Infusion of galanin caused a rapid, reversible and dose-dependent reduction in basal insulin level. A maximal increase in blood glucose level accompanying the insulin decrease was observed when galanin was administered at a dose of 4 mug/kg per h. Pancreatic glucagon levels showed little change compared with basal secretion. These results indicate that galanin is involved in the regulation of glucose through control of insulin secretion.