Leptin is a metabolic signal to the reproductive system
Leptin is a metabolic signal to the reproductive system
复制标题
DOI：
10.1210/en.137.7.3144
复制
发表时间：
1996-07-01
期刊：
影响因子：
4.8
通讯作者：
Steiner, RA
中科院分区：
文献类型：
--
作者：
Barash, IA;Cheung, CC;Steiner, RA
瘦素是一种新发现的肥胖基因的激素产物，由脂肪细胞表达，被认为在调节食物摄入和代谢中起作用。我们测试的假设，瘦素的信号代谢信息的生殖系统，检查其对生殖系统的ob/ob小鼠，有一个先天性缺乏瘦素和不育的影响。我们用瘦素（50 μ g，每日两次，ip）或赋形剂（n=10/组）处理成对喂养的雄性和雌性动物14天，之后将动物流血的并处死。与对照组相比，瘦素处理的雌性动物血清LH水平显著升高，卵巢和子宫重量增加，卵巢和子宫组织学方面受到刺激。与对照组相比，瘦素处理的雄性动物血清FSH水平显著升高，睾丸和精囊重量增加，精囊上皮细胞高度增加，精子计数升高。这些结果表明，瘦素刺激生殖内分泌系统在两种性别的ob/ob小鼠，并建议瘦素可能作为一个允许的信号，正常动物的生殖系统。
Leptin, a newly-discovered hormonal product of the obese (ob) gene, is expressed by adipocytes and thought to play a role in the regulation of food intake and metabolism. We tested the hypothesis that leptin signals metabolic information to the reproductive system by examining its effects on the reproductive system of ob/ob mice, which have a congenital deficiency in leptin and are infertile. We treated pair-fed males and females with leptin (50 mu g twice daily, ip) or vehicle (n=10/group) for 14 days, after which the animals were bled and killed. Leptin-treated females had significantly elevated serum levels of LH, increased ovarian and uterine weights, and stimulated aspects of ovarian and uterine histology compared to controls. Leptin-treated males had significantly elevated serum levels of FSH, increased testicular and seminal vesicle weights, greater seminal vesicle epithelial cell height, and elevated sperm counts compared to controls. These results demonstrate that leptin stimulates the reproductive endocrine system in both sexes of ob/ob mice and suggest that leptin may serve as a permissive signal to the reproductive system of normal animals.