Immunoprophylactic effect of chicken egg yolk immunoglobulin (Ig Y) against porcine epidemic diarrhea virus (PEDV) in piglets
Immunoprophylactic effect of chicken egg yolk immunoglobulin (Ig Y) against porcine epidemic diarrhea virus (PEDV) in piglets
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DOI：
10.1292/jvms.62.961
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发表时间：
2000-09-01
影响因子：
1.2
通讯作者：
Lee, YS
中科院分区：
文献类型：
--
作者：
Kweon, CH;Kwon, BJ;Lee, YS
猪流行性腹泻病毒（Porcine epidemic diarrhea virus，PEDV）是引起仔猪腹泻的主要病原，其致死率很高。本研究以新生仔猪为试验动物，研究了鸡卵黄免疫球蛋白（IG Y）对PEDV的免疫预防作用。发现IG Y可降低攻击暴露后仔猪的死亡率。IG Y的田间应用还显示，与安慰剂或对照相比，给予IG Y的仔猪的存活率存在显著差异。本研究的结果表明，抗PEDV的Tg Y可能是补充预防措施（如母猪初乳抗体）的替代方法。
Porcine epidemic diarrhea virus (PEDV) is the causative agent of neonatal diarrhea in piglets, which causes high mortality rates. In this study, the immunoprophylactic effects of chicken egg yolk immunoglobulin (Ig Y) against PEDV were investigated in neonatal pigs. Ig Y was found to reduce the mortality in piglets after challenge exposures. The field application of Ig Y also revealed significant differences in survival rates of piglets given Ig Y, as compared with placebo or control. The results in this study indicated that Tg Y against PEDV could be an alternative way of supplementing prophylactic measures like colostral antibodies from sows.